Choline intake in a large cohort of patients with nonalcoholic fatty liver disease
Choline intake in a large cohort of patients with nonalcoholic fatty liver disease
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DOI：
10.3945/ajcn.111.020156
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发表时间：
2012-04-01
影响因子：
7.1
通讯作者：
Scheimann, Ann O.
中科院分区：
文献类型：
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作者：
Guerrerio, Anthony L.;Colvin, Ryan M.;Scheimann, Ann O.
背景资料：在非酒精性脂肪性肝病（NAFLD）和胆碱缺乏相关的脂肪性肝炎之间存在显著的组织学和生化重叠。目的：我们试图确定经活检证实的NAFLD和胆碱摄入不足的证据是否具有更严重的组织学特征。设计：我们对664名参加多中心研究的受试者进行了横断面分析，前瞻性非酒精性脂肪性肝炎临床研究网络（NASH CRN），肝脏活检6个月内的饮食组成基线数据（来自基于召回的食物频率问卷）。食物调查问卷用专有软件进行分析，以估计每日胆碱摄入量。集中读取肝活检，并使用NASH CRN开发的评分系统对共识进行评分。由于胆碱需求因年龄、性别和绝经状态而异，因此根据医学研究所对胆碱充足摄入量（AI）的定义，将参与者分为相应的类别（9-13岁的儿童，≥ 14岁的男性，绝经前女性≥ 19岁，绝经后女性）。摄入不足的定义为
Background: There is significant histologic and biochemical overlap between nonalcoholic fatty liver disease (NAFLD) and steatohepatitis associated with choline deficiency.Objective: We sought to determine whether subjects with biopsy-proven NAFLD and evidence of an inadequate intake of choline had more severe histologic features.Design: We performed a cross-sectional analysis of 664 subjects enrolled in the multicenter, prospective Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) with baseline data on diet composition (from a recall-based food-frequency questionnaire) within 6 mo of a liver biopsy. Food questionnaires were analyzed with proprietary software to estimate daily intakes of choline. Liver biopsies were centrally read, and consensus was scored with the NASH CRN developed scoring system. Because choline needs vary by age, sex, and menopausal status, participants were segregated into corresponding categories (children 9-13 y old, males >= 14 y old, premenopausal women >= 19 y old, and postmenopausal women) on the basis of the Institute of Medicine's definition of adequate intake (AI) for choline. Deficient intake was defined as