The heritability of risk and age at onset of Parkinson's disease after accounting for known genetic risk factors.
The heritability of risk and age at onset of Parkinson's disease after accounting for known genetic risk factors.
复制标题
DOI：
10.1038/jhg.2010.13
复制
发表时间：
2010-04
影响因子：
3.5
通讯作者：
中科院分区：
文献类型：
--
作者：
我们质疑白人PD遗传成分的证据是否可以用已经确定的致病基因和易感基因来解释。我们在504个核心家庭（2,828人）的样本中估计了PD发病风险和年龄的遗传度。排除已知致病突变的家系并考虑主要易感基因后，发生PD风险的遗传度为0.41（P=0.01）。这些数据表明，PD易感性的变化中约有40%是由于尚未鉴定的基因，其余可能是环境因素。
We questioned if the evidence for the genetic component in PD in Caucasians could be explained by the causative and susceptibility genes that have already been identified. We estimated heritability of risk and age at onset of PD in a well-characterized sample of 504 nuclear families (2,828 individuals). After excluding families with known pathogenic mutations and accounting for the major susceptibility genes, the heritability of the risk of developing PD was 0.41 (P=0.01). These data suggest approximately 40% of the variation in susceptibility to PD is due to as yet unidentified genes, the remainder is likely environmental.
登录
查看更多内容
影响因子：
30.8
作者：
Satake, Wataru;Nakabayashi, Yuko;Toda, Tatsushi
通讯作者：
Toda, Tatsushi
影响因子：
9.8
作者：
Almasy, L;Blangero, J
通讯作者：
Blangero, J
影响因子：
11.2
作者：
McDonnell, SK;Schaid, DJ;Rocca, WA
通讯作者：
Rocca, WA
影响因子：
9.8
作者：
Maraganore, DM;de Andrade, M;Ballinger, DG
通讯作者：
Ballinger, DG
影响因子：
11.2
作者：
Zabetian, Cyrus P.;Hutter, Carolyn M.;Payami, Haydeh
通讯作者：
Payami, Haydeh