The Role of Inflammatory Response in Stroke Associated Programmed Cell Death.
The Role of Inflammatory Response in Stroke Associated Programmed Cell Death.
复制标题
DOI：
10.2174/1570159x16666180222155833
复制
发表时间：
2018
影响因子：
5.3
通讯作者：
Jurajda M
中科院分区：
文献类型：
--
作者：
Duris K;Splichal Z;Jurajda M
中风代表了与高发病率和死亡率相关的破坏性病理学。由中风发作直接引起的初始损伤，即原发性损伤，可能会被继发性损伤所掩盖，继发性损伤可能对大脑产生更大的破坏性影响。原发性损伤主要与由于致命的氧和葡萄糖不足引起的坏死性细胞死亡相关。相反，继发性损伤可能由于与细胞功能不相容或甚至可能代表恶性转化的危险的结构损伤而导致凋亡性细胞死亡。免疫系统负责监视、防御和愈合过程，并且免疫系统在触发程序性细胞死亡中起主要作用。严重的病理，如中风，通常与免疫系统失调有关，导致继发性脑损伤加重。本文就免疫系统在脑卒中的病理生理学中的作用、脑卒中后神经细胞程序性死亡以及针对炎症的治疗策略进行综述
Stroke represents devastating pathology which is associated with a high morbidity and mortality. Initial damage caused directly by the onset of stroke, primary injury, may be eclipsed by secondary injury which may have a much more devastating effect on the brain. Primary injury is predominantly associated with necrotic cell death due to fatal insufficiency of oxygen and glucose. Secondary injury may on the contrary, lead apoptotic cell death due to structural damage which is not compatible with cellular functions or which may even represent the danger of malign transformation. The immune system is responsible for surveillance, defense and healing processes and the immune system plays a major role in triggering pro-grammed cell death. Severe pathologies, such as stroke, are often associated with deregulation of the immune system, result-ing in aggravation of secondary brain injury. The goal of this article is to overview the current knowledge about the role of immune system in the pathophysiology of stroke with respect to programmed neuronal cell death as well as to discuss cur-rent therapeutic strategies targeting inflammation after stroke