STAT3 as an adapter to couple phosphatidylinositol 3-kinase to the IFNAR1 chain of the type I interferon receptor
STAT3 as an adapter to couple phosphatidylinositol 3-kinase to the IFNAR1 chain of the type I interferon receptor
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DOI：
10.1126/science.276.5317.1418
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发表时间：
1997-05-30
期刊：
影响因子：
56.9
通讯作者：
Yang, CH
中科院分区：
文献类型：
--
作者：
Pfeffer, LM;Mullersman, JE;Yang, CH
STAT（signal transducers and activators of transcription）蛋白在丝氨酸和酪氨酸上经历丝氨酸依赖性磷酸化，STAT 3是急性期反应基因的转录因子，被发现在I型干扰素受体的信号转导中充当接头分子。STAT 3与受体IFNAR 1链胞质尾区的保守序列结合，并经历干扰素依赖性酪氨酸磷酸化。磷脂酰肌醇S-激酶的p85调节亚基激活一系列丝氨酸激酶，与磷酸化的STAT 3结合并随后经历酪氨酸磷酸化，因此，STAT 3作为接头将另一个信号通路偶联到干扰素受体。
STAT (signal transducers and activators of transcription) proteins undergo cytokine-dependent phosphorylation on serine and tyrosine, STAT3, a transcription factor for acute phase response genes, was found to act as an adapter molecule in signal transduction from the type I interferon receptor. STAT3 bound to a conserved sequence in the cytoplasmic tail of the IFNAR1 chain of the receptor and underwent interferon-dependent tyrosine phosphorylation. The p85 regulatory subunit of phosphatidylinositol S-kinase, which activates a series of serine kinases, bound to phosphorylated STAT3 and subsequently underwent tyrosine phosphorylation, Thus, STAT3 acts as an adapter to couple another signaling pathway to the interferon receptor.