PLGA/polymeric liposome for targeted drug and gene co-delivery
PLGA/polymeric liposome for targeted drug and gene co-delivery
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用于靶向药物和基因共递送的 PLGA/聚合物脂质体
DOI：
10.1016/j.biomaterials.2010.07.082
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发表时间：
2010-11-01
期刊：
影响因子：
14
通讯作者：
Chang, Jin
中科院分区：
文献类型：
--
作者：
Wang, Hanjie;Zhao, Peiqi;Chang, Jin
化疗是临床上治疗癌症最有效的方法之一，但多药耐药、低生物利用度和毒性等问题严重制约了化疗的进一步应用。我们的团队最近报道了阳离子PLGA/叶酸包被聚乙二醇聚合物脂质体核壳纳米粒子（PLGA/FPL NPs）。它是由疏水性PLGA核心和亲水性叶酸包被聚乙二醇脂质壳自组装而成的，用于靶向药物和基因的共递送。疏水药物可以掺入核内，载药纳米颗粒的阳离子壳可以用来结合DNA。负载药物的PLGA/FPL NPs/DNA复合物具有克服上述问题的优势，例如药物和DNA的共同递送在基因水平上提高癌细胞的化学敏感性，以及靶向递送药物到癌症组织以提高生物利用度和降低毒性。实验表明，该纳米颗粒具有纳米大小的核壳结构，具有药物缓释特性和良好的dna结合能力。重要的是，核壳纳米颗粒实现了将药物和基因共同递送到同一细胞的可能性，具有较高的基因转染和药物递送效率。我们的数据表明，PLGA/FPL NPs可能是一种有用的药物和基因共递送系统。(C) 2010 Elsevier Ltd.版权所有。
Chemotherapy is one of the most effective approaches to treat cancers in the clinic, but the problems, such as multidrug resistance (MDR), low bioavailability and toxicity, severely constrain the further application of chemotherapy. Our group recently reported that cationic PLGA/folate coated PEGlated polymeric liposome core shell nanoparticles (PLGA/FPL NPs). It was self-assembled from a hydrophobic PLGA core and a hydrophilic folate coated PEGlated lipid shell for targeting co-delivery of drug and gene. Hydrophobic drugs can be incorporated into the core and the cationic shell of the drug-loaded nanoparticles can be used to bind DNA. The drug-loaded PLGA/FPL NPs/DNA complexes offer advantages to overcome these problems mentioned above, such as co-delivery of drugs and DNA to improving the chemosensitivity of cancer cells at a gene level, and targeting delivery of drug to the cancer tissue that enhance the bioavailability and reduce the toxicity. The experiment showed that nanoparticles have core shell structure with nanosize, sustained drug release profile and good DNA-binding ability. Importantly, the core shell nanoparticles achieve the possibility of co-delivering drugs and genes to the same cells with high gene transfection and drug delivery efficiency. Our data suggest that the PLGA/FPL NPs may be a useful drug and gene co-delivery system. (C) 2010 Elsevier Ltd. All rights reserved.