Mapping of a susceptibility locus for Crohn's disease on chromosome 16
Mapping of a susceptibility locus for Crohn's disease on chromosome 16
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DOI：
10.1038/379821a0
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发表时间：
1996-02-29
期刊：
影响因子：
64.8
通讯作者：
Thomas, G
中科院分区：
文献类型：
--
作者：
Hugot, JP;LaurentPuig, P;Thomas, G
克罗恩病（CD）和溃疡性结肠炎是西方世界慢性炎症性肠病的主要形式，并且发生在年轻成年人中，估计患病率超过每千名居民中的一名。炎症性肠病的病因尚不清楚，但遗传流行病学研究（2-5）表明，遗传因素可能部分导致克罗恩病个体易感性的变化。使用非参数两点同胞对连锁方法，对两个连续和独立的多个受影响成员的家庭小组进行全基因组搜索，在16号染色体上鉴定出一个推定的CD易感基因座（每组P < 0.01）。通过使用多点同胞对分析，定位集中在基因座D16 S409和D16 S419周围（参考文献6和J.M.O.，（P < 1.5 × 10（-5））。该基因组区域包含可能与炎症性肠病的致病机制相关的候选基因。
Crohn's disease (CD) and ulcerative colitis are the major forms of chronic inflammatory bowel diseases in the western world, and occur in young adults with an estimated prevalence of more than one per thousand inhabitants'. The causes of inflammatory bowel diseases remain unknown, but genetic epidemiology studies(2-5) suggest that inherited factors may contribute in part to variation in individual susceptibility to Crohn's disease. A genome-wide search performed on two consecutive and independent panels of families with multiple affected members, using a non-parametric two-point sibling-pair linkage method, identified a putative CD-susceptibility locus on chromosome 16 (P < 0.01 for each panel). The localization was centred around loci D16S409 and D16S419 by using multipoint sibpair analysis (ref. 6, and J.M.O., manuscript submitted) (P < 1.5 x 10(-5)). This region of the genome contains candidate genes which may be relevant to the pathogenic mechanism of inflammatory bowel diseases.