Determination of octanol-water partition coefficients of pesticides by microemulsion electrokinetic chromatography
Determination of octanol-water partition coefficients of pesticides by microemulsion electrokinetic chromatography
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DOI：
10.1016/s0021-9673(01)01171-2
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发表时间：
2001-09-28
影响因子：
4.1
通讯作者：
Foley, JP
中科院分区：
文献类型：
--
作者：
Klotz, WL;Schure, MR;Foley, JP
微乳液电动色谱（MEEKC）是一种间接测定农药正辛醇-水分配系数（log P-o/w）的筛选工具。研究了80多个代表各种结构特征的农药化合物，发现log P-o/w与保留因子的对数具有良好的相关性，所研究的微乳液系统允许在log P-o/w为-1到7的范围内分离化合物。此外，一个较小的一组简单的有机分子，不同的结构特征进行了评估，并比较农药log P-o/w校准。农药和简单有机分子log P-o/w校准线在统计学上相似。这表明，一套通用的标准化合物可以用于log P-o/w。校准以提供具有良好准确度的各种化合物的测量。(C)2001 Elsevier Science B. V.保留所有权利。
Microemulsion electrokinetic chromatography (MEEKC) was evaluated as a screening tool for the indirect measurement of octanol-water partition coefficients (log P-o/w of pesticide compounds. Over 80 pesticide compounds representing a variety of structural characteristics were studied, and good correlation of log P-o/w with the logarithm of the retention factor was found. The microemulsion system studied allowed the separation of compounds in the log P-o/w range of -1 to 7. In addition, a smaller set of simple organic molecules that vary in structural features was evaluated and compared to the pesticide log P-o/w calibration. The pesticide and simple organic molecule log P-o/w calibration lines were statistically similar. This suggests that a universal set of standard compounds may be employed for the log P-o/w. calibration to provide measurements for a variety of compounds with good accuracy. (C) 2001 Elsevier Science B.V. All rights reserved.