GE11 Peptide as an Active Targeting Agent in Antitumor Therapy: A Minireview.
GE11 Peptide as an Active Targeting Agent in Antitumor Therapy: A Minireview.
复制标题
DOI：
10.3390/pharmaceutics10010002
复制
发表时间：
2017-12-22
期刊：
影响因子：
5.4
通讯作者：
Dorati R
中科院分区：
文献类型：
--
作者：
Genta I;Chiesa E;Colzani B;Modena T;Conti B;Dorati R
许多实体瘤的特征在于由与细胞生长相关的受体触发的不受控制的信号转导。用抗肿瘤药物靶向这些细胞受体对于提高化疗疗效至关重要。这可以通过将活性靶向剂缀合至装载有抗肿瘤药物的胶体药物递送系统的聚合物部分来实现。这篇小综述的目的是报告和讨论GE 11肽结合胶体药物递送系统作为抗肿瘤药物的智能载体靶向表皮生长因子受体的一些最新结果。小综述章节将重点解释和讨论：（i）表皮生长因子受体（EGFR）的结构和功能;（ii）GE 11的结构和生物活性;（iii）GE 11缀合和GE 11缀合药物递送系统的示例。其基本原理是有助于收集有关主动靶向肿瘤的信息。介绍了GE 11肽与聚合物纳米颗粒结合靶向肿瘤细胞的研究。
A lot of solid tumors are characterized by uncontrolled signal transduction triggered by receptors related to cellular growth. The targeting of these cell receptors with antitumor drugs is essential to improve chemotherapy efficacy. This can be achieved by conjugation of an active targeting agent to the polymer portion of a colloidal drug delivery system loaded with an antitumor drug. The goal of this minireview is to report and discuss some recent results in epidermal growth factor receptor targeting by the GE11 peptide combined with colloidal drug delivery systems as smart carriers for antitumor drugs. The minireview chapters will focus on explaining and discussing: (i) Epidermal growth factor receptor (EGFR) structures and functions; (ii) GE11 structure and biologic activity; (iii) examples of GE11 conjugation and GE11-conjugated drug delivery systems. The rationale is to contribute in gathering information on the topic of active targeting to tumors. A case study is introduced, involving research on tumor cell targeting by the GE11 peptide combined with polymer nanoparticles.
登录
查看更多内容
影响因子：
2.9
作者：
Huber, Lucas A.;Pereira, Tatiana A.;Lopez, Renata F. V.
通讯作者：
Lopez, Renata F. V.
影响因子：
4.7
作者：
Chariou PL;Lee KL;Wen AM;Gulati NM;Stewart PL;Steinmetz NF
通讯作者：
Steinmetz NF
影响因子：
5.8
作者：
Haeri, Azadeh;Zalba, Sara;Koning, Gerben A.
通讯作者：
Koning, Gerben A.
影响因子：
5.8
作者：
Colzani, Barbara;Speranza, Giovanna;Genta, Ida
通讯作者：
Genta, Ida
影响因子：
1.5
作者：
Colzani, Barbara;Biagiotti, Marco;Genta, Ida
通讯作者：
Genta, Ida