Hypocretin/orexin-containing neurons are produced in one sharp peak in the developing ventral diencephalon
Hypocretin/orexin-containing neurons are produced in one sharp peak in the developing ventral diencephalon
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DOI：
10.1111/j.1460-9568.2005.04224.x
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发表时间：
2005-07-01
影响因子：
3.4
通讯作者：
Risold, PY
中科院分区：
文献类型：
--
作者：
Amiot, C;Brischoux, F;Risold, PY
使用溴脱氧尿苷法分析大鼠中含有下丘脑分泌素的神经元的出生日期。结果表明，这些神经元是在胚胎第 11 天 (E11) 和 E14 之间产生的，在 E12 时达到峰值。这种发生的时空模式与下丘脑外侧区域共同分布的产生黑色素浓缩激素的神经元的时空模式形成鲜明对比，后者被描述为在 E10 至 E16 的一个大峰中产生。这些观察结果可能与两个种群的相对分布区域有关。
The birth date of hypocretin-containing neurons was analysed using the bromodeoxyuridine method in the rat. The results indicate that these neurons are generated between embryonic days 11 (E11) and E14, with a sharp peak on E12. This spatiotemporal pattern of genesis contrasts with that of the co-distributed neurons producing the melanin-concentrating hormone in the lateral hypothalamic area, which have been described as generated in one large peak from E10 to E16. These observations may be linked to the relative distribution area of both populations.