Is Research on "Synthetic Cells" Moving to the Next Level?
Is Research on "Synthetic Cells" Moving to the Next Level?
复制标题
DOI：
10.3390/life9010003
复制
发表时间：
2018-12-26
期刊：
影响因子：
3.2
通讯作者：
Stano, Pasquale
中科院分区：
文献类型：
--
作者：
Stano, Pasquale
“合成细胞”研究的重点是通过使用具有仿生结构的充满溶质的人工微区室来构建细胞样模型。近年来，这种自下而上的合成生物学领域取得了相当大的进展，该领域目前正在经历快速扩张。在这里，我们总结了一些技术和理论方面的合成细胞的基础上基因表达和其他酶的反应内脂质体，并评论最新的趋势。这样的参观将是一个机会，让我们询问向新型SC原型进行质的飞跃的时机是否已经成熟：对“合成细胞”的研究是否正在迈向一个新的水平？
"Synthetic cells" research focuses on the construction of cell-like models by using solute-filled artificial microcompartments with a biomimetic structure. In recent years this bottom-up synthetic biology area has considerably progressed, and the field is currently experiencing a rapid expansion. Here we summarize some technical and theoretical aspects of synthetic cells based on gene expression and other enzymatic reactions inside liposomes, and comment on the most recent trends. Such a tour will be an occasion for asking whether times are ripe for a sort of qualitative jump toward novel SC prototypes: is research on "synthetic cells" moving to a next level?