Clinical profile of various sub-types of writer's cramp
Clinical profile of various sub-types of writer's cramp
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DOI：
10.1016/j.parkreldis.2007.01.009
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发表时间：
2007-01-01
影响因子：
4.1
通讯作者：
Truong, Daniel
中科院分区：
文献类型：
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作者：
Das, Chandi Prasad;Prabhakar, Sudesh;Truong, Daniel
我们分析了141例连续的书写痉挛（WC）患者。简单WC（n = 108）的平均（SD）病程为3.65（2.7）年，Burke-Fahn-马尔登（BFM）量表（手写评分：0-4）的严重程度评分为2.8（0.91），而复杂WC（n = 33）的病程为5.8（2.81）年，严重程度评分为3.6（0.52）。与局灶性WC相比，全身性WC患者病程长、致残率高、年龄大。镜像肌张力障碍65例（46.1%）。Meige综合征（n = 4）和颈部肌张力障碍（n = 6）并存。部分患者仅在书写时出现颈部姿势异常（n = 5）和口下颌区姿势异常（n = 3）。在治疗后1个月，接受肉毒杆菌毒素治疗的患者的情况明显好于口服治疗的患者。(C)2007爱思唯尔有限公司保留所有权利。
We profiled 141 consecutive patients of writer's cramp (WC). Simple WC (n = 108) had a mean (SD) disease duration of 3.65 (2.7) years and a severity score of 2.8 (0.91) by Burke-Fahn-Marden (BFM) scale (handwriting score: 0-4), whereas complex WC (n = 33) had a disease duration of 5.8 (2.81) years and severity score of 3.6 (0.52). Compared with focal WC, generalized WC cases had longer disease duration, severer disability, and were older. Mirror dystonia was seen in 65 patients (46.1%). Co-existent Meige's syndrome (n = 4) and cervical dystonia (n = 6) were seen. Some patients had abnormal posturing of the neck (n = 5) and of the oromandibular region (n = 3) only while writing. Those receiving botulinum toxin fared significantly better than those on oral therapy, at 1 month post treatment. (C) 2007 Elsevier Ltd. All rights reserved.