Fish, meat, and risk of dementia:: cohort study
Fish, meat, and risk of dementia:: cohort study
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DOI：
10.1136/bmj.325.7370.932
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发表时间：
2002-10-26
影响因子：
--
通讯作者：
Renaud, S
中科院分区：
文献类型：
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作者：
Barberger-Gateau, P;Letenneur, L;Renaud, S
我们从PAQUID （Personnes ag<s:1> QUID）认知和功能衰老流行病学研究中获得数据。healthandage。net/html/min/paquid/entrance。htm)。在第三波研究（1991-2）期间，调查人员访问了法国西南部75个教区的1674名68岁及以上没有痴呆症的人，并记录了他们食用肉类和鱼类或海鲜的频率：每天，每周至少一次（但不是每天），偶尔（但不是每周），从不。参与者分别在2年、5年和7年后接受了随访：1416人（84.6%）至少接受了一次随访。所有自上次访问以来在迷你精神状态检查中损失3分或以上的参与者，或根据《精神疾病诊断与统计手册》第三版修订（DSM-III-R）的标准怀疑患有痴呆症的参与者，都由神经科医生访问以确认诊断。我们计算了每100人年的痴呆发病率。我们使用延迟进入的Cox比例风险模型来估计痴呆的相对风险，考虑到年龄、性别和教育（至少法国小学文凭“Certificat d’etudes Primaires”与教育程度较低3）。
We obtained data from the PAQUID (Personnes Agées QUID) epidemiological study of cognitive and functional ageing (www. healthandage. net/html/min/paquid/entrance. htm). During the third wave of the study (1991-2) investigators visited 1674 people aged 68 and over without dementia and living at home in 75 parishes in southwestern France and recorded their frequency of consumption of meat and fish or seafood: daily, at least once a week (but not every day), from time to time (but not every week), never. Participants were followed up two, five, and seven years afterwards: 1416 (84.6%) had at least one follow up visit. All the participants who had lost three points or more on the mini-mental state examination since a previous visit or were suspected of having dementia according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders, third edition, revised (DSM-III-R) were visited by a neurologist to confirm the diagnosis.We calculated the incidence of dementia per 100 person years. We used a Cox proportional hazards model with delayed entry to estimate the relative risk of dementia, taking into account age, sex, and education (at least the French primary school diploma “Certificat d'Etudes Primaires” versus less education 3).