Simian herpesviruses and their risk to humans
Simian herpesviruses and their risk to humans
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DOI：
10.1016/j.vaccine.2009.11.026
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发表时间：
2010-05-26
期刊：
影响因子：
5.5
通讯作者：
Wong, Scott W.
中科院分区：
文献类型：
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作者：
Estep, Ryan D.;Messaoudi, Ilhem;Wong, Scott W.
与人类高度的遗传和生理同源性使非人类灵长类动物（NHP）成为生物医学研究的重要动物模型。因此，NHP 提供了一个独特的机会来研究物种中宿主与病原体的相互作用，该物种密切模仿人类生物学，但仍可以在严格的实验室条件下维持。事实上，使用 NHP 进行的研究对于我们了解发病机制以及疫苗和治疗方法的开发至关重要。 NHP 对多种与人类病原体具有显着同源性的病原体敏感这一事实进一步促进了这一点。不幸的是，这些病毒也给人类带来了潜在的健康问题。在这篇综述中，我们讨论了猿猴疱疹病毒及其在与其密切接触的研究人员中引起疾病的可能性。 (C) 2009 Elsevier Ltd. 保留所有权利。
A high level of genetic and physiological homology with humans has rendered non-human primates (NHP) an essential animal model for biomedical research. As such NHP offer a unique opportunity to study host-pathogen interactions in a species that closely mimics human biology but can yet be maintained under tight laboratory conditions. Indeed, studies using NHP have been critical to our understanding of pathogenesis as well as the development of vaccines and therapeutics. This further facilitated by the fact that NHPs are susceptible to a variety of pathogens that bear significant homology to human pathogens. Unfortunately, these same viruses pose a potential health issue to humans. In this review we discuss the simian herpesviruses and their potential to cause disease in researchers that come into close contact with them. (C) 2009 Elsevier Ltd. All Fights reserved.