Stress, depression and medication nonadherence in diabetes: test of the exacerbating and buffering effects of family support
Stress, depression and medication nonadherence in diabetes: test of the exacerbating and buffering effects of family support
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DOI：
10.1007/s10865-014-9611-4
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发表时间：
2015-04-01
影响因子：
3.1
通讯作者：
Osborn, Chandra Y.
中科院分区：
文献类型：
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作者：
Mayberry, Lindsay Satterwhite;Egede, Leonard E.;Osborn, Chandra Y.
应激源和抑郁症状与成人2型糖尿病（T2DM）患者的药物依从性相关。我们在192名患有T2DM和低社会经济地位的成年人样本中，使用未调整和调整的回归模型，测试了这些关联是被阻碍性家庭行为加剧还是被支持性家庭行为缓冲。我们找到了支持恶化假说的证据。应激源和不依从性仅与高水平的阻塞性家庭行为相关（相互作用AOR = 1.12, p = 0.002）。同样，抑郁症状和不依从性仅与高水平的阻碍性家庭行为相关（相互作用AOR = 3.31, p = 0.002）。当参与者报告很少的阻碍性家庭行为时，压力源和抑郁症状都与不依从性无关。我们没有找到支持缓冲假说的证据；压力源和抑郁症状与不依从性相关，无论支持的家庭行为如何。经历压力源和/或重度抑郁症状的非依从性患者可能受益于减少妨碍性家庭行为的干预。
Stressors and depressive symptoms have been associated with medication nonadherence among adults with type 2 diabetes (T2DM). We tested whether these associations were exacerbated by obstructive family behaviors or buffered by supportive family behaviors in a sample of 192 adults with T2DM and low socioeconomic status using unadjusted and adjusted regression models. We found support for the exacerbating hypothesis. Stressors and nonadherence were only associated at higher levels of obstructive family behaviors (interaction AOR = 1.12, p = .002). Similarly, depressive symptoms and nonadherence were only associated at higher levels of obstructive family behaviors (interaction AOR = 3.31, p = .002). When participants reported few obstructive family behaviors, neither stressors nor depressive symptoms were associated with nonadherence. We did not find support for the buffering hypothesis; stressors and depressive symptoms were associated with nonadherence regardless of supportive family behaviors. Nonadherent patients experiencing stressors and/or major depressive symptoms may benefit from interventions that reduce obstructive family behaviors.