Role of CXCR4 and SDF1 as prognostic factors for survival and the association with clinicopathology in colorectal cancer: A systematic meta-analysis
Role of CXCR4 and SDF1 as prognostic factors for survival and the association with clinicopathology in colorectal cancer: A systematic meta-analysis
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DOI：
10.1177/1010428317706206
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发表时间：
2017-06-16
期刊：
影响因子：
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通讯作者：
Cui, Yongping
中科院分区：
文献类型：
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作者：
Li, Yao-ping;Pang, Jing;Cui, Yongping
C-X-C趋化因子受体4和基质细胞衍生因子-1已被证明在几种类型的癌症和与肿瘤生长、侵袭、血管生成和转移相关的许多生物学过程中发挥重要作用。然而，C-X-C趋化因子受体4型和基质细胞衍生因子-1在结直肠癌中表达的临床意义仍然不准确。本系统性荟萃分析的目的是研究C-X-C趋化因子受体4型和基质细胞衍生因子-1作为生存预后因素的作用，以及C-X-C趋化因子受体4型/基质细胞衍生因子-1与结直肠癌临床病理学之间的关系。检索数据库包括PubMed、EMBASE和科克伦图书馆，以查找更新至2017年1月的相关文献。使用Review Manager 5.3进行数据分析。在我们的荟萃分析中，C-X-C趋化因子受体4型表达与肿瘤淋巴结转移阶段、肿瘤分化程度、肝转移、淋巴结转移、远处转移和诊断相关，未观察到C-X-C趋化因子受体4型表达与肿瘤大小、性别、术前癌胚抗原、年龄或血管浸润相关。基质细胞衍生因子-1的表达与肿瘤的淋巴结转移分期、淋巴结转移、血管侵犯、年龄、性别、远处转移、诊断无关。基质细胞衍生因子-1的表达与肿瘤分化程度有关。此外，无病生存期/总生存期的合并风险比显示，C-X-C趋化因子受体4型/基质细胞衍生因子-1的过表达降低了结直肠癌的无病生存期/总生存期。因此，C-X-C趋化因子受体4/基质细胞衍生因子-1的高表达可以预测结直肠癌患者的不良生存率，为结直肠癌患者的预后提供更好的线索。
C-X-C chemokine receptor type 4 and stromal cell-derived factor-1 were proven to play important roles in several types of cancer and in many biological processes connected with tumor growth, invasion, angiogenesis, and metastasis. However, the clinical significance of C-X-C chemokine receptor type 4 and stromal cell-derived factor-1 expression in colorectal cancer remains inaccurate. The purpose of this systematic meta-analysis is to investigate the role of C-X-C chemokine receptor type 4 and stromal cell-derived factor-1 as prognostic factors for survival and the association between C-X-C chemokine receptor type 4/ stromal cell-derived factor-1 and clinicopathology in colorectal cancer. Databases including PubMed, EMBASE, and Cochrane Library were searched for relevant literatures updated till January 2017. Review Manager 5.3 was used for data analysis. In our meta-analysis, C-X-C chemokine receptor type 4 expression is related to tumor-node-metastasis stage, tumor differentiation, liver metastasis, lymph node metastasis, distant metastasis, and diagnosis, and no correlation of C-X-C chemokine receptor type 4 expression with tumor size, gender, preoperative carcinoembryonic antigen, age, or vascular invasion has been observed. Stromal cell-derived factor-1 expression has no relationship with tumor-node-metastasis stage, lymph node metastasis, vascular invasion, age, gender, distant metastasis, or diagnosis. The expression of stromal cell-derived factor-1 has association with tumor differentiation. Moreover, the pooled hazard ratio for disease-free survival/overall survival showed that overexpression of C-X-C chemokine receptor type 4/stromal cell-derived factor-1 reduced disease-free survival/overall survival in colorectal cancer. Therefore, High expression of C-X-C chemokine receptor type 4/stromal cell-derived factor-1 which is essential in tumor progression can predict poor survival that may provide more advance prognostic clues to colorectal cancer patients.