Evolution of Complementary Peptide Systems Teneurin C-terminal-associated Peptides and Corticotropin-releasing Factor Superfamilies
Evolution of Complementary Peptide Systems Teneurin C-terminal-associated Peptides and Corticotropin-releasing Factor Superfamilies
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DOI：
10.1111/j.1749-6632.2008.03629.x
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发表时间：
2009-01-01
期刊：
影响因子：
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通讯作者：
Barsyte-Lovejoy, Dalia
中科院分区：
文献类型：
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作者：
Lovejoy, David A.;Rotzinger, Susan;Barsyte-Lovejoy, Dalia
在脊索动物中，促肾上腺皮质激素释放因子（CRF）家族的肽由四个旁系同源谱系组成，包括CRE、尿皮质素/尿加压素-I、尿皮质素2和尿皮质素3。在昆虫中发现的利尿激素家族与CRF肽家族相关。这个科由昆虫纲内的一些旁系同源谱系组成。特奈林C-末端相关肽（TCAP）是最近描述的一个家族的肽与CRF家族的进化起源大约相同的时间。该家族由脊索动物中的四个独立谱系组成，它们与昆虫纲中的肽类是直向的。与CRF一样，肽的长度为40或41个氨基酸，与CRF家族成员共有约20%的序列同一性。四种TCAP肽中的每一种都由与teneurin基因密切相关的外显子编码。最近的研究表明，TCAP可以阻断CRF介导的脑内c-fos表达，并调节CRF介导的行为。因此，TCAP家族可以部分地调节CRF家族的生理作用。
In chordates, the corticotropin-releasing factor (CRF) family of peptides consists of four paralogous lineages that include CRE, urocortin/urotensin-I, urocortin 2, and urocortin 3. Related to the CRF peptide family is the diuretic hormone family found in insects. This family consists of a number of paralogous lineages within the Insecta. The teneurin C-terminal-associated peptides (TCAP) are a recently described family of peptides with evolutionary origins around the same time as the CRF family. This family consists of four independent lineages in chordates that are orthologous to peptides in the Insecta. Like CRF, the peptides are 40 or 41 amino acids in length and share about 20% sequence identity to the CRF family members. Each of the four TCAP peptides is encoded by an exon that is closely associated with the teneurin gene. Recent studies indicate that TCAP can block CRF-mediated c-fos expression in the brain and modulate CRF-mediated behaviors. Thus, the TCAP family may act, in part, to modulate the physiological actions of the CRF family.