Treatment planning comparison of conventional, 3D conformal, and intensity-modulated photon (IMRT) and proton therapy for paranasal sinus carcinoma
Treatment planning comparison of conventional, 3D conformal, and intensity-modulated photon (IMRT) and proton therapy for paranasal sinus carcinoma
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DOI：
10.1016/s0360-3016(03)01452-4
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发表时间：
2004-01-01
影响因子：
7
通讯作者：
Pötter, R
中科院分区：
文献类型：
--
作者：
Mock, U;Georg, D;Pötter, R
目的：为了确定潜在的改善与鼻窦癌患者通过比较质子和调强放疗（IMRT）与常规和适形光子treatment planning techniques.Methods and Materials：在5例患者中，比较治疗计划进行比较质子计划和相关的常规，适形，和IMRT光子计划。评价分析了靶体积和危险器官（OAR，即，结果：所有技术的平均和最大剂量、剂量不均匀性和计划靶体积的符合性指数是可比的。与相应的质子计划相比，光子计划在10-70%剂量水平下导致更大体积的辐照非靶组织。因此，常规放疗的体积增加了1.3-3.1倍，适形放疗增加了1.1-3.8倍，调强放疗增加了1.1-3.7倍。与传统技术相比，适形和IMRT光子治疗计划选项同样降低了OAR的平均剂量。质子的使用进一步降低了平均剂量的OARs高达65%和62%相比，与适形和调强放射治疗technique，respectively.Conclusion：与传统的治疗技术相比，适形放射治疗和调强放射治疗同样使剂量减少的OARs。使用基于质子的治疗计划模式获得了额外的改善。(C)2004爱思唯尔公司
Purpose: To determine the potential improvements in patients with paranasal sinus carcinoma by comparing proton and intensity-modulated radiotherapy (IMRT) with conventional and conformal photon treatment planning techniques.Methods and Materials: In 5 patients, comparative treatment planning was performed by comparing proton plans and related conventional, conformal, and IMRT photon plans. The evaluations analyzed dose-volume histogram findings of the target volumes and organs at risk (OARs, i.e., pituitary gland, optical pathway structures, brain, nontarget tissue).Results: The mean and maximal doses, dose inhomogeneities, and conformity indexes for the planning target volumes were comparable for all techniques. Photon plans resulted in greater volumes of irradiated nontarget tissues at the 10-70% dose level compared with the corresponding proton plans. The volumes thereby increased by a factor of 1.3-3.1 for conventional, 1.1-3.8 for conformal, and 1.1-3.7 for IMRT. Compared with conventional techniques, conformal and IMRT photon treatment planning options similarly reduced the mean dose to the OARs. The use of protons further reduced the mean dose to the OARs by up to 65% and 62% compared with the conformal and IMRT technique, respectively.Conclusion: Compared with conventional treatment techniques, conformal RT and IMRT similarly enabled dose reductions to the OARs. Additional improvements were obtained using proton-based treatment planning modalities. (C) 2004 Elsevier Inc.