STRUCTURALLY BASED INCREASE OF FLOW RESISTANCE IN SPONTANEOUSLY HYPERTENSIVE RATS
STRUCTURALLY BASED INCREASE OF FLOW RESISTANCE IN SPONTANEOUSLY HYPERTENSIVE RATS
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DOI：
10.1111/j.1748-1716.1970.tb04737.x
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发表时间：
1970-01-01
期刊：
影响因子：
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通讯作者：
WEISS, L
中科院分区：
文献类型：
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作者：
FOLKOW, B;HALLBACK, M;WEISS, L
在自发性高血压大鼠（SHR）和正常血压对照组中比较了最大扩张的全身血管床（冠状动脉除外）的流动阻力。- 在主动脉根部插管，用含氧血浆替代品灌注，连续记录右心的主动脉流入和静脉流出。灌注液的温度和粘度保持恒定，并使用超大剂量的血管扩张药物检查完全血管舒张即将到来。绘制压力-流量曲线，并比较相等压头和跨壁压下的流阻。- 在自发性高血压大鼠中，最大扩张的全身血管中的流动阻力增加到在很大程度上等于其在“静息”条件下升高的血压，与对照动物的差异非常显著。- 结果表明，存在一个形态适应的阻力血管的整个系统电路，提高了结构设置的“基线”的功能血管的调整，因此，这可能在很大程度上占在休息时增加的流动阻力。这些发现与早期关于高血压患者局部血流阻力的研究一致（Folkow 1956，Sivertsson和Olander 1968）。
The resistance to flow in the maximally dilated systemic vascular bed (except the coronaries) was compared in spontaneously hypertensive rats (SHR) and normotensive controls. – The aortic root was cannulated for perfusion with an oxygenated plasma substitute, both the aortic inflow and the venous effluentviathe right heart being recorded continuously. Temperature and viscosity of the perfusate were kept constant and it was checked with supramaximal doses of vasodilator drugs that complete vascular relaxation was at hand. Pressure‐flow curves were plotted and flow resistances at equal pressure heads and transmural pressures were compared. — Flow resistance in the maximally dilated systemic vessels was increased in the spontaneously hypertensive rats to an extent that largely equalled their raised blood pressure during “resting” conditions, the difference to the control animals being highly significant. – The results suggest the presence of a morphological adaptation of the resistance vessels of the entire systemic circuit which raises the structurally set “baseline” for functional vascular adjustments, and which therefore may largely account for the increased flow resistance during rest. These findings are in agreement with earlier studies concerning the regional flow resistance in hypertensive man (Folkow 1956, Sivertsson and Olander 1968).