Growth factor regulation of interleukin-1 beta-induced nitric oxide synthase and GTP: cyclohydrolase expression in cultured smooth muscle cells.
Growth factor regulation of interleukin-1 beta-induced nitric oxide synthase and GTP: cyclohydrolase expression in cultured smooth muscle cells.
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生长因子对白细胞介素 1 β 诱导的一氧化氮合酶和 GTP 的调节：培养平滑肌细胞中环水解酶的表达。
DOI：
10.1006/bbrc.1993.2388
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发表时间：
1993
影响因子：
3.1
通讯作者：
Vanhoutte,PM
中科院分区：
文献类型：
--
作者：
Scott-Burden,T;Elizondo,E;Ge,T;Boulanger,CM;Vanhoutte,PM
白细胞介素1β诱导培养的大鼠腹主动脉血管平滑肌细胞NO合酶表达的同时，还诱导了GTP：环化水解酶I的表达。该酶调节四氢生物蝶呤的新生合成途径，四氢生物蝶呤是通过诱导型NO合酶将L-精氨酸催化转化为L-瓜氨酸和NO的必要辅因子。抑制GTP：环化水解酶减弱白细胞介素-1 β刺激的平滑肌细胞产生NO。肽类生长因子如成纤维细胞生长因子、血小板衍生生长因子和转化生长因子β1以及蛋白酶凝血酶已被证明可调节精氨酸处理的平滑肌细胞产生NO。这些肽激动剂还调节NO合酶和GTP环化水解酶mRNA表达的诱导。
Induction of NO synthase expression by interleukin-1β in cultured vascular smooth muscle cells from rat aortas was accompanied by simultaneous induction of GTP: cyclohydrolase I. This enzyme regulates thede novosynthesis pathway for tetrahydrobiopterin, an essential cofactor for the catalytic conversion of L-arginine to L-citrulline and NO by inducible NO synthase. Inhibition of GTP: cyclohydrolase attenuated NO production by interleukin-1β-stimulated smooth muscle cells. Peptide growth factors such as fibroblast growth factor, platelet-derived growth factor and transforming growth factorβ1 and the protease thrombin have been shown to modulate the production NO by cytokine-treated smooth muscle cells. These peptide agonists also regulated the induction of NO synthase and GTP: cyclohydrolase mRNA expression.