The effects of nutritional manipulation and laboratory selection on lifespan in Drosophila melanogaster
The effects of nutritional manipulation and laboratory selection on lifespan in Drosophila melanogaster
复制标题
DOI：
10.1093/gerona/54.5.b192
复制
发表时间：
1999-05-01
影响因子：
5.1
通讯作者：
Rose, MR
中科院分区：
文献类型：
--
作者：
Nusbaum, TJ;Rose, MR
实验室选择和营养调控对果蝇寿命和其他适合度相关性状表达的影响存在相似之处，但同时进行实验室选择和营养调控的影响却知之甚少。鉴于D，黑腹果蝇是测试衰老理论的主要模式生物之一，同时应用实验室选择和营养操作是相当感兴趣的。为此，我们开发了六组五倍重复的群体，选择早期或晚期生育。这些组中的每一个都保持在高营养或低营养饮食中，Le组之间的比较表明，营养在选择寿命方面是中性的。此外，饮食限制反应可以通过同时选择和营养操纵来打破。最后，在选择或营养操纵下以平行方式反应的性状在同时施用这两种物质时可能不会。
There are parallels between the effects of laboratory selection and nutritional manipulation on the expression of lifespan and other fitness-related characters in Drosophila melanogaster, However, little is known about the effects of laboratory selection and nutritional manipulation when applied simultaneously. Given that D, melanogaster is one of the major model organisms for testing theories of aging, simultaneous application of laboratory selection and nutritional manipulation is of considerable interest. To that end, we developed six groups of fivefold replicated population selected for either early or late fertility. Each of these groups was maintained on either high- or low-nutrition diets, Comparisons among Le groups showed that nutrition is neutral in selecting for lifespan. Moreover, the dietary-restriction response can he broken by simultaneous selection and nutritional manipulation. Finally, characters that respond in a parallel manner under selection or nutritional manipulation may not when the two ore applied simultaneously.