Ca2+ Signaling in Oligodendrocyte Development
Ca2+ Signaling in Oligodendrocyte Development
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DOI：
10.1007/s10571-019-00705-4
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发表时间：
2019-06
影响因子：
4
通讯作者：
Ming Zhang;Yuming Liu;Shengxi Wu;Xianghui Zhao
中科院分区：
文献类型：
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作者：
Ming Zhang;Yuming Liu;Shengxi Wu;Xianghui Zhao
钙信号在神经系统的发育中起着重要的作用，从神经诱导到神经元和神经胶质细胞的增殖、迁移和分化。Ca2+信号的时间和空间动态控制着建立神经系统复杂结构的高度多样但特异的转录程序。Ca2+信号通路是由代谢型信号级联、离子通道、细胞内Ca2+储存和众多激活特定遗传程序的下游效应蛋白之间的相互作用形成的。在过去的十年中取得的进展，导致我们的理解的功能架构的少突胶质细胞发育中涉及的Ca2+信号网络的显着进步。本文综述了少突胶质细胞分化过程中Ca2+信号网络的分子和功能组织，特别是其对髓鞘基因表达、增殖、迁移和髓鞘形成的影响。重要的是，多种途径的Ca2+内流的存在打开了这样的可能性，即可以操纵钙通道的活性，从而促进脑中脱髓鞘事件后的少突胶质细胞成熟和髓鞘再生。
Calcium signaling has essential roles in the development of the nervous system, from neural induction to the proliferation, migration, and differentiation of both neuronal and glia cells. The temporal and spatial dynamics of Ca2+signals control the highly diverse yet specific transcriptional programs that establish the complex structures of the nervous system. Ca2+-signaling pathways are shaped by interactions among metabotropic signaling cascades, ion channels, intracellular Ca2+stores, and a multitude of downstream effector proteins that activate specific genetic programs. Progress in the last decade has led to significant advances in our understanding of the functional architecture of Ca2+signaling networks involved in oligodendrocyte development. In this review, we summarize the molecular and functional organizations of Ca2+-signaling networks during the differentiation of oligodendrocyte, especially its impact on myelin gene expression, proliferation, migration, and myelination. Importantly, the existence of multiple routes of Ca2+influx opens the possibility that the activity of calcium channels can be manipulated pharmacologically to encourage oligodendrocyte maturation and remyelination after demyelinating episodes in the brain.