Prostaglandin I2 enhances cough reflex sensitivity to capsaicin in the asthmatic airway.
Prostaglandin I2 enhances cough reflex sensitivity to capsaicin in the asthmatic airway.
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DOI：
10.1186/1745-9974-3-2
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发表时间：
2007-01-12
期刊：
影响因子：
--
通讯作者：
Myou S
中科院分区：
文献类型：
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作者：
Ishiura Y;Fujimura M;Nobata K;Oribe Y;Abo M;Myou S
炎症介质参与了气道炎症的发病机制，但前列腺素I2（PGI2）的作用仍不清楚。本研究旨在探讨PGI2在哮喘气道咳嗽反射敏感性中的作用，哮喘气道以慢性嗜酸性粒细胞性气道炎症为特征。在一项随机、安慰剂对照的交叉研究中，在21例稳定型哮喘患者中检查了贝前列素（一种化学和生物学稳定的PGI2类似物）对吸入辣椒素引起的咳嗽反应的影响。辣椒素咳嗽阈值，定义为引起五次或更多次咳嗽的辣椒素的最低浓度，被测量为气道咳嗽反射敏感性的指数。与安慰剂[30.3（GSEM 1.21）μ M]相比，贝前列素[17.8（GSEM 1.20）μ M]治疗两周后咳嗽阈值显著降低（p < 0.05）。PGI2增加哮喘气道咳嗽反射敏感性，表明抑制PGI2可能是哮喘患者，特别是咳嗽为主的哮喘患者的一种新的治疗选择。
Inflammatory mediators are involved in the pathogenesis of airway inflammation, but the role of prostaglandin I2 (PGI2) remains obscure. This study was designed to investigate the role of PGI2 in cough reflex sensitivity of the asthmatic airway, which is characterized by chronic eosinophilic airway inflammation. The effect of beraprost, a chemically and biologically stable analogue of PGI2, on cough response to inhaled capsaicin was examined in 21 patients with stable asthma in a randomized, placebo-controlled cross over study. Capsaicin cough threshold, defined as the lowest concentration of capsaicin eliciting five or more coughs, was measured as an index of airway cough reflex sensitivity. The cough threshold was significantly (p < 0.05) decreased after two weeks of treatment with beraprost [17.8 (GSEM 1.20) μM] compared with placebo [30.3 (GSEM 1.21) μM]. PGI2 increases cough reflex sensitivity of the asthmatic airway, suggesting that inhibition of PGI2 may be a novel therapeutic option for patients with asthma, especially cough predominant asthma.