Novel approaches for oral delivery of macromolecules
Novel approaches for oral delivery of macromolecules
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DOI：
10.1021/js980076h
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发表时间：
1998-11-01
影响因子：
3.8
通讯作者：
Fasano, A
中科院分区：
文献类型：
--
作者：
Fasano, A
不可吸收药物和肽的传统给药形式通常依赖于肠胃外注射，因为肠上皮对这些治疗剂的渗透性很差。最近开发了许多创新的药物递送方法，包括将药物包埋在小囊泡内或通过肠道旁细胞途径。闭塞小带毒素是一种最近发现的由霍乱弧菌合成的蛋白质，它提供了工具来获得更多关于通过细胞旁途径调节肠道通透性的病理生理学的见解，并开发了通常不通过肠道吸收的药物和大分子口服给药的替代方法。
Traditional forms of administrations of nonabsorbable drugs and peptides often rely on their parenteral injection, since the intestinal epithelium is poorly permeable to these therapeutical agents. A number of innovative drug delivery approaches have been recently developed, including the drug entrapment within small vesicles or their passage through the intestinal paracellular pathway. Zonula occludens toxin, a recently discovered protein elaborated by Vibrio cholerae, provided tools to gain more insights on the pathophysiology of the regulation of intestinal permeability through the paracellular pathway and to develop alternative approaches for the oral delivery of drugs and macromolecules normally not absorbed through the intestine.