Survivin expression in early hepatocellular carcinoma and post-treatment with anti-cancer drug under hypoxic culture condition
Survivin expression in early hepatocellular carcinoma and post-treatment with anti-cancer drug under hypoxic culture condition
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DOI：
10.3748/wjg.v13.i40.5306
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发表时间：
2007-10-28
影响因子：
4.3
通讯作者：
Tajiri, Hisao
中科院分区：
文献类型：
--
作者：
Mamori, Satoshi;Asakura, Tadashi;Tajiri, Hisao
目的：为探讨生存素（Survivin）在肝细胞癌（HCC）早期的表达情况，采用免疫组化方法检测17例HCC患者肝肿瘤组织和非肿瘤组织中Survivin的表达。此外，为了确定生存素的表达在早期肝癌的抗癌药物的反应，生存素的表达后，肝癌细胞与抗癌药物治疗后，在缺氧culture.Results：生存素蛋白表达在64.7%的细胞在早期肝癌标本。生存素在癌周肝细胞中的表达率和在HCC标本中的表达率之间存在相关性（低表达率组vs高表达率组）。结论：缺氧联合抗肿瘤药物可使肝癌细胞中Survivin蛋白表达增加，提示Survivin可作为早期肝癌治疗的靶点。(C)2007年WJG。All rights reserved.
AIM: To investigate the expression of survivin during the early stages of hepatocellular carcinoma (HCC).METHODS: Immunohistochemical expression of survivin in liver tumor and non-tumor tissue specimens taken from 17 patients was compared. In addition, to determine the survivin expression in response to anticancer drugs in early stage HCC, the survivin expression was determined after the treatment of the HCC cells with anti-cancer drugs under hypoxic culture conditions.RESULTS: Survivin proteins were expressed in 64.7% of cells in early HCC specimens. A correlation between the survivin expression rate in the peritumoral hepatocytes and the rate of expression in the HCC specimens (low-rate group vs high-rate group) was observed. The survivin protein concentration in HCC cells was increased by the combination of hypoxia and anti-cancer drugs.CONCLUSION: This study suggests that survivin could be used as a therapeutic target in early HCC. (C) 2007 WJG. All rights reserved.