Association of Lps gene with natural resistance of mouse macrophages against Legionella pneumophila.
Association of Lps gene with natural resistance of mouse macrophages against Legionella pneumophila.
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Lps 基因与小鼠巨噬细胞对嗜肺军团菌的天然抵抗力的关联。
DOI：
10.1111/j.1574-6968.1991.tb04970.x
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Y. Mizuguchi
中科院分区：
文献类型：
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作者：
S. Yoshida;Y. Goto;H. Miyamoto;H. Fujio;Y. Mizuguchi
从脂多糖（LPS）-低应答C3 H/HeJ小鼠（J）获得的腹膜巨噬细胞允许（J × N）F1子代的巨噬细胞中细菌的细胞内生长，其介于亲本菌株之间，表明性状共显性表达。检测了巨噬细胞内细菌生长与脾细胞LPS反应之间的相关性。F_2、（J × F_1）回交和（N × F_1）回交后代中，两因子间呈负相关。这一结果表明LPS基因控制小鼠巨噬细胞对细菌的先天抗性。虽然A/J株巨噬细胞也允许L. A/J和C_3H/HeJ小鼠的基因互补分析表明，C_3H/HeJ小鼠的基因控制不同于A/J株。与C57 BL/10小鼠相比，C57 BL/10 ScN的巨噬细胞（其是从C57 BL/10获得的LPS低应答细胞系）在控制细菌生长方面也有缺陷。我们认为Lps基因也控制着小鼠巨噬细胞对L.嗜肺菌
Peritoneal macrophages obtained from lipopolysaccharide (LPS)-low responder C3H/HeJ mice (J) permitted the intracellular growth of the bacterium in macrophages of (J x N) F1 progeny was between the parent strains, showing that the traits were co-dominantly expressed. Correlation between intracellular bacterial growth in macrophages and LPS response of spleen cells was examined. Negative correlation was found between the two factors in F2, (J x F1) backcross and (N x F1) backcross progeny. This result implies that Lps gene controls the innate resistance of murine macrophages against the bacteria. Although macrophages of A/J strain also permit intracellular growth of L. pneumophila, gene complementation analysis of A/J and C3H/HeJ mice made clear that the gene control in C3H/HeJ differs from that of A/J strain. Macrophages of C57BL/10ScN, which is LPS-low responder line obtained from C57BL/10, were also defective in controlling the bacterial growth when compared to C57BL/10 mice. We suggest that the Lps gene also controls the natural resistance of murine macrophages against L. pneumophila.
C3H/HeJ 和 C3HeB/FeJ 小鼠中单独的遗传缺陷影响革兰氏阴性菌感染易感性的证据。
DOI：
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发表时间：
1985
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Hagberg,L;Briles,DE;Eden,CS
通讯作者：
Eden,CS
脂多糖的生物活性脂质部分激活蛋白激酶 C。
DOI：
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发表时间：
1984
期刊：
The Journal of biological chemistry
影响因子：
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作者：
Wightman,PD;Raetz,CR
通讯作者：
Raetz,CR
更多证据表明 Lps 基因位点调节小鼠对鼠伤寒沙门氏菌的天然抵抗力。
DOI：
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发表时间：
1985
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
O'Brien,AD;Weinstein,DA;Soliman,MY;Rosenstreich,DL
通讯作者：
Rosenstreich,DL