Neurological involvement of COVID-19: from neuroinvasion and neuroimmune crosstalk to long-term consequences
Neurological involvement of COVID-19: from neuroinvasion and neuroimmune crosstalk to long-term consequences
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DOI：
10.1515/revneuro-2020-0092
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发表时间：
2021-05-01
影响因子：
4.1
通讯作者：
Susilowati, Rina
中科院分区：
文献类型：
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作者：
Septyaningtrias, Dian Eurike;Susilowati, Rina
随着 2019 年冠状病毒病 (COVID-19) 大流行继续对人类构成多方面的威胁，越来越多的证据表明与其相关的神经系统受累。神经免疫相互作用可能被证明不仅在神经系统表现的发病机制中很重要，而且对于预防全身性过度炎症也很重要。在这篇综述中，我们总结了涉及神经系统的 COVID-19 病例的报告，随后讨论了可能的进入途径、中枢神经系统针对冠状病毒感染的免疫反应以及病毒感染和免疫反应引起的神经变性的机制。还讨论了神经保护和病毒相关神经系统后果的可能机制。
As the coronavirus disease 2019 (COVID-19) pandemic continues to be a multidimensional threat to humanity, more evidence of neurological involvement associated with it has emerged. Neuroimmune interaction may prove to be important not only in the pathogenesis of neurological manifestations but also to prevent systemic hyperinflammation. In this review, we summarize reports of COVID-19 cases with neurological involvement, followed by discussion of possible routes of entry, immune responses against coronavirus infection in the central nervous system and mechanisms of nerve degeneration due to viral infection and immune responses. Possible mechanisms for neuroprotection and virus-associated neurological consequences are also discussed.