Association of the Serum Uric Acid-to-Creatinine Ratio with Nonalcoholic Fatty Liver Disease Diagnosed by Computed Tomography
Association of the Serum Uric Acid-to-Creatinine Ratio with Nonalcoholic Fatty Liver Disease Diagnosed by Computed Tomography
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DOI：
10.1089/met.2020.0086
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发表时间：
2020-12-14
影响因子：
2.1
通讯作者：
Han, A. Lum
中科院分区：
文献类型：
--
作者：
Seo, Yoo Bin;Han, A. Lum
背景：尽管已有研究表明血尿酸/肌酐比值(Sua/Cr)与代谢综合征有关，但有关Sua/Cr与非酒精性脂肪性肝病(NAFLD)之间关系的证据有限。方法：对778名健康体检者进行横断面分析。参与者根据NAFLD的存在进行分组，这是通过腹部计算机断层扫描(CT)确定的。对NAFLD的相关变量进行Logistic回归分析，并估计NAFLD的调整优势比(OR)。结果：NAFLD患者的SuA/Cr显著高于非NAFLD患者。多因素分析显示SuA/Cr值与NAFLD显著相关，SuA/Cr值增加1对NAFLD的校正OR值为1.182。(95%可信区间：1.066-1.311)。结论：在健康成人中，尿酸/肌酸比值升高与CT诊断的非酒精性脂肪肝显著相关。SuA/Cr可能是预测NAFLD的可靠指标。(临床试验注册号：2020-06-002-002)
Background: Although previous studies have suggested that the serum uric acid-to-creatinine ratio (sUA/Cr) is associated with metabolic syndrome, there is limited evidence of a relationship between sUA/Cr and nonalcoholic fatty liver disease (NAFLD). In this study, we investigated the association between sUA/Cr and NAFLD in healthy adults.Methods: A cross-sectional analysis was performed in 778 subjects who participated in a health examination. The participants were divided according to presence of NAFLD, which was determined by abdominal computed tomography (CT). Logistic regression analysis was performed to investigate the variables associated with NAFLD, and an adjusted odds ratio (OR) of sUA/Cr for NAFLD was estimated.Results: sUA/Cr in participants with NAFLD was significantly higher than in those without NAFLD. Multivariate analysis demonstrated significant association between sUA/Cr and NAFLD, and the adjusted OR of sUA/Cr increase of 1 for NAFLD was 1.182. (95% CI: 1.066-1.311).Conclusions: Elevated sUA/Cr was significantly associated with CT-diagnosed NAFLD in healthy adults. sUA/Cr may be a reliable marker for predicting NAFLD.(The Clinical Trial Registration number: 2020-06-002-002)