Controlled breathing protocols probe human autonomic cardiovascular rhythms
Controlled breathing protocols probe human autonomic cardiovascular rhythms
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DOI：
10.1152/ajpheart.1998.274.2.h709
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发表时间：
1998-02-01
影响因子：
4.8
通讯作者：
Eckberg, DL
中科院分区：
文献类型：
--
作者：
Cooke, WH;Cox, JF;Eckberg, DL
本研究的目的是确定需要不同程度控制的呼吸方案如何影响心血管动力学。我们测量了 10 名志愿者的吸气量、呼气末 CO2、R-R 间期和动脉压频谱功率，这些志愿者遵循以下 5 种呼吸方案：1) 不受控制的呼吸 5 分钟； 2) 逐步频率呼吸（0.3、0.25、0.2、0.15、0.1 和 0.05 Hz，每次 2 分钟）； 3) 如上所述的逐步频率呼吸，但具有规定的潮气量； 4）随机频率呼吸（类似于0.5-0.05 Hz）6分钟； 5) 固定频率呼吸 (0.25 Hz) 5 分钟。在逐步呼吸期间，R-R间期和动脉压频谱功率随着呼吸频率的降低而增加。控制吸气量可降低 0.1 Hz 呼吸期间的 R-R 间隔频谱功率 (P < 0.05)。逐步和随机呼吸方案在呼吸和 R-R 间隔以及收缩压和 R-R 间隔之间产生了可比较的一致性和传递函数。随机和固定频率呼吸适度降低呼气末二氧化碳浓度（P < 0.05）。我们的数据表明，严格的潮气量控制会减弱低频 R-R 间隔振荡，固定和随机速率呼吸可能会减少 CO2 化学感受器刺激。我们得出的结论是，在不同呼吸方案中测量的自主节律有很多共同点，但没有严格控制吸气量的逐步方案可能可以最有效地评估短期呼吸介导的自主振荡。
The purpose of this study was to determine how breathing protocols requiring varying degrees of control affect cardiovascular dynamics. We measured inspiratory volume, end-tidal CO2, R-R interval, and arterial pressure spectral power in 10 volunteers who followed the following 5 breathing protocols: 1) uncontrolled breathing for 5 min; 2) stepwise frequency breathing (at 0.3, 0.25, 0.2, 0.15, 0.1, and 0.05 Hz for 2 min each); 3) stepwise frequency breathing as above, but with prescribed tidal volumes; 4) random-frequency breathing (similar to 0.5-0.05 Hz) for 6 min; and 5) fixed-frequency breathing (0.25 Hz) for 5 min. During stepwise breathing, R-R interval and arterial pressure spectral power increased as breathing frequency decreased. Control of inspired volume reduced R-R interval spectral power during 0.1 Hz breathing (P < 0.05). Stepwise and random-breathing protocols yielded comparable coherence and transfer functions between respiration and R-R intervals and systolic pressure and R-R intervals. Random-and fixed-frequency breathing reduced end-tidal CO2 modestly (P < 0.05). Our data suggest that stringent tidal volume control attenuates low-frequency R-R interval oscillations and that fixed-and random-rate breathing may decrease CO2 chemoreceptor stimulation. We conclude that autonomic rhythms measured during different breathing protocols have much in common but that a stepwise protocol without stringent control of inspired volume may allow for the most efficient assessment of short-term respiratory-mediated autonomic oscillations.