Change in Prescription Habits After Federal Rescheduling of Hydrocodone Combination Products
Change in Prescription Habits After Federal Rescheduling of Hydrocodone Combination Products
复制标题
联邦重新安排氢可酮组合产品后处方习惯的变化
作者：
Susan Seago;A. Hayek;J. Pruszynski;M. Newman
在全国范围内，2012年，医疗保健提供者为麻醉镇痛药开出了2.59亿张处方，或者说每个美国成年人大约有一瓶麻醉药。为了解决这个日益严重的问题，美国缉毒局于2014年10月6日将氢可酮组合产品的附表从附表III更改为附表II。在德克萨斯州中部200英里半径范围内的14家Baylor Scott &白色药店，在重新安排之前和之后询问了氢可酮/对乙酰氨基酚，吗啡，可待因/对乙酰氨基酚和曲马多的处方信息，以评估处方药使用的趋势。虽然重新安排氢可酮复方产品的处方数量和氢可酮/对乙酰氨基酚5/325 mg的分发总量减少，（诺科5/325）和10/325 mg（诺科10/325）制剂，这被替代麻醉镇痛药（如曲马多、可待因/对乙酰氨基酚30/300 mg）的急剧增加所抵消（Tylenol#3）和可待因/对乙酰氨基酚60/300 mg（Tylenol#4），其不具有附表II要求。此外，在将所有药物转换为吗啡当量后，处方的总止痛药没有显著减少。
Nationally, health care providers wrote 259 million prescriptions for narcotic analgesics in 2012, or roughly one bottle of narcotics per US adult (1). In an effort to combat this ever-growing problem, the Drug Enforcement Administration changed the schedule of hydrocodone combination products from schedule III to schedule II on October 6, 2014. Fourteen Baylor Scott & White pharmacies encompassing a 200-mile radius in Central Texas were queried for prescription information on hydrocodone/acetaminophen, morphine, codeine/acetaminophen, and tramadol before and after the rescheduling to evaluate trends in prescription drug usage. While the rescheduling of hydrocodone combination products resulted in a reduced number of prescriptions and the total quantity dispensed of both the hydrocodone/acetaminophen 5/325 mg (Norco 5/325) and 10/325 mg (Norco 10/325) formulations, this was offset by a dramatic increase in alternative narcotic analgesics such as tramadol, codeine/acetaminophen 30/300 mg (Tylenol #3), and codeine/ acetaminophen 60/300 mg (Tylenol #4), which do not have schedule II requirements. Additionally, there was no significant reduction in total pain medication prescribed after converting all agents to morphine equivalents.
影响因子：
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作者：
Anne Depriest;Brandi L. Puet;A. Holt;A. Roberts;E. Cone
通讯作者：
Anne Depriest;Brandi L. Puet;A. Holt;A. Roberts;E. Cone