Natural medicine combined with nanobased topical delivery systems: a new strategy to treat psoriasis
Natural medicine combined with nanobased topical delivery systems: a new strategy to treat psoriasis
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DOI：
10.1007/s13346-021-01031-3
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发表时间：
2021-07
影响因子：
5.4
通讯作者：
Zhiyue Zhao;Tao Liu;Sha Zhu;Jiaxin Pi;Pan Guo;Dongli Qi;Zhidong Liu;Nan Li
中科院分区：
文献类型：
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作者：
Zhiyue Zhao;Tao Liu;Sha Zhu;Jiaxin Pi;Pan Guo;Dongli Qi;Zhidong Liu;Nan Li
牛皮癣是一种自身免疫性炎症性皮肤病，是影响全球个体的最常见的免疫介导疾病之一。目前，传统的银屑病治疗方法存在疗效有限、刺激皮肤、免疫抑制等缺点。因此，对于科学家来说，找到一种更有效的替代药物治疗牛皮癣是很重要的。由于天然药物在各种给药途径中具有治疗意义，因此仍然是新药发现的重要来源。然而，银屑病局部治疗的传统配方在功效上是有限的，这限制了天然药物的使用。基于上述局限性，在制备这些外用草药产品中使用纳米载体可以极大地增强外用药物的功效。越来越多的证据表明，纳米载体在透皮制剂中的应用作为一种有前景的技术，具有更好的效力，将药物吸收引导到作用部位，以及最小的毒性效应。本文就银屑病的发病机制、天然药物配方、天然药物活性成分以及纳米制剂在银屑病治疗中的应用进行了综述。图形抽象
Psoriasis, an autoimmune inflammatory skin disorder, is one of the commonest immune-mediated disease conditions affecting individuals globally. At the moment, the conventional methods applied against psoriasis treatment have various drawbacks involving limited efficacy, skin irritation, immunosuppression, etc. Therefore, it is important for scientists to find a more potent and alternative drug approach towards psoriasis therapeutics. Natural medicine still remains an important source for new drug discovery due to its therapeutical significance in various drug administration routes. However, the traditional formulation of topical therapies for psoriasis is limited in efficacy, which limits the use of natural medicine. Based on the aforementioned limitations, the use of nanocarriers in preparation of these topical herbal products could be tremendously beneficial in enhancing the efficacy of topical medications. Growing pieces of evidence have proposed that the utilization of nanocarriers in transdermal preparation as a prospective technique, with regards to better potency, directs drug absorption to site of action, and minimum toxicity effect respectively. In the course of this review, we emphasized the pathological mechanism of psoriasis, natural medicine formula, active components of natural medicine, and nanopreparations used in the treatment of psoriasis.Graphical abstract