FAMILY HISTORY IN RECURRENT DEPRESSION
FAMILY HISTORY IN RECURRENT DEPRESSION
复制标题
DOI：
10.1016/0165-0327(89)90033-5
复制
发表时间：
1989-09-01
影响因子：
6.6
通讯作者：
NEISWANGER, K
中科院分区：
文献类型：
--
作者：
KUPFER, DJ;FRANK, E;NEISWANGER, K
作者报告了179名复发性抑郁症先证者的一级亲属中发现的抑郁、酗酒和双相情感障碍的病态风险。对亲属的性别、先证者的性别和先证者的发病年龄进行了比较。结果显示，非双相抑郁的总体患病风险为20.7%，酒精中毒的总患病风险为15.4%，双相情感障碍的总患病风险为1.1%。研究发现，女性亲属患抑郁症的风险比男性更大，而酗酒的情况正好相反。先证者的性别没有影响。与晚发性先证者相比，早发性先证者亲属的风险显著增加。检查了发病年龄的不同截止年龄，随着截止年龄降低到20岁，影响变得更加明显。
The authors report morbid risks found for depression, alcoholism and bipolar disorder in first-degree relatives of 179 probands with recurrent depression. Comparisons were made for relatives'' gender, probands'' gender, and probands'' age at onset. Results showed overall morbid risks of 20.7% for non-bipolar depression, 15.4% for alcoholism, and 1.1% for bipolar disorder. Female relatives were found to be at greater risk for depression than males, while the reverse was true for alcoholism. Sex of proband had no effect. Risk to relatives of early-onset probands was significantly elevated compared to late-onset probands. Various cutoffs for ages at onset were examined, and the effect became more marked as the cutoff age was decreased to 20.