Antiobesity and lipid-lowering effects of Bifidobacterium spp. in high fat diet-induced obese rats.
Antiobesity and lipid-lowering effects of Bifidobacterium spp. in high fat diet-induced obese rats.
复制标题
DOI：
10.1186/1476-511x-10-116
复制
发表时间：
2011-07-12
影响因子：
4.5
通讯作者：
Ha NJ
中科院分区：
文献类型：
--
作者：
An HM;Park SY;Lee DK;Kim JR;Cha MK;Lee SW;Lim HT;Kim KJ;Ha NJ
最近的研究报告了益生菌对肥胖的预防作用。在益生菌中，双歧杆菌是哺乳动物肠道中数量最多的益生菌之一，是乳酸菌的一种。本研究的目的是评估双歧杆菌的减肥和降脂作用。分离自健康韩国人的高脂饮食诱导的肥胖大鼠。将36只雄性Sprague-Dawley大鼠分为三组：（1）SD组，饲喂标准饮食;（2）HFD组，饲喂高脂饮食;和（3）HFD-LAB组，饲喂补充有LAB补充剂的高脂饮食（B. pseudocatenulatum SPM 1204，B. longum SPM 1205和B. longum SPM 1207; 108 ~ 109 CFU）。7周后，测量身体、器官和脂肪重量、食物摄入量、血清水平、粪便LAB计数和有害酶活性。LAB给药降低了体重和脂肪重量、血清水平（TC、HDL-C、LDL-C、甘油三酯、葡萄糖、瘦素、AST、ALT和脂肪酶水平）和有害酶活性（β-葡萄糖苷酶、β-葡萄糖醛酸苷酶和葡聚糖酶），并显著增加了粪便LAB计数。这些数据表明，双歧杆菌属。在这项研究中使用可能有有益的减肥效果。
Recent studies have reported the preventive effects of probiotics on obesity. Among commensal bacteria, bifidobacteria is one of the most numerous probiotics in the mammalian gut and are a type of lactic acid bacteria. The aim of this study was to assess the antiobesity and lipid-lowering effects of Bifidobacterium spp. isolated from healthy Korean on high fat diet-induced obese rats. Thirty-six male Sprague-Dawley rats were divided into three groups as follows: (1) SD group, fed standard diet; (2) HFD group, fed high fat diet; and (3) HFD-LAB group, fed high fat diet supplemented with LAB supplement (B. pseudocatenulatum SPM 1204, B. longum SPM 1205, and B. longum SPM 1207; 108 ~ 109 CFU). After 7 weeks, the body, organ, and fat weights, food intake, blood serum levels, fecal LAB counts, and harmful enzyme activities were measured. Administration of LAB reduced body and fat weights, blood serum levels (TC, HDL-C, LDL-C, triglyceride, glucose, leptin, AST, ALT, and lipase levels), and harmful enzyme activities (β-glucosidase, β-glucuronidase, and tryptophanase), and significantly increased fecal LAB counts. These data suggest that Bifidobacterium spp. used in this study may have beneficial antiobesity effects.