Investigating the role of brain-derived neurotrophic factor in relapsing-remitting multiple sclerosis
Investigating the role of brain-derived neurotrophic factor in relapsing-remitting multiple sclerosis
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DOI：
10.1111/j.1601-183x.2006.00245.x
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发表时间：
2007-03-01
影响因子：
2.5
通讯作者：
Quattrone, A.
中科院分区：
文献类型：
--
作者：
Liguori, M.;Fera, F.;Quattrone, A.
多发性硬化症（MS）是一种常见的，异质性的中枢神经系统疾病，具有由遗传和环境因素组成的复杂特征。最近，科学界对定义可能影响脑功能可塑性的因素的兴趣有所增加;结果可能有助于评估MS病变负担与临床事件之间的关系，并解释该疾病众所周知的表型异质性。在这项研究中，我们探讨了Val 66 Met脑源性神经营养因子（BDNF）功能多态性对认知性能和体积测量的影响，通过磁共振成像的大脑中的复发缓解型MS（RRMS）患者，相对较短的病程和最小的临床残疾，与性别，年龄和教育水平匹配的健康受试者相比。我们发现在RRMS组中，BDNF Met等位基因与脑灰质（GM）体积降低显著相关（P = 0.005）。此外，一个显着的（P = 0.013）之间的相互作用的影响“MS状态”和BDNF基因型被发现的GM体积，结果是，携带BDNF Met等位基因的患者表现出更高的风险发展全球GM萎缩比纯合子瓦尔/瓦尔。在RRMS患者或对照组中，没有BDNF相关的对整体神经心理功能的影响。我们的数据似乎是一致的BDNF在神经元可塑性的影响，从而表明，Met等位基因可能有一个负面的预后影响RRMS患者的皮质形态。
Multiple sclerosis (MS) is a common, heterogeneous disorder of the central nervous system with a complex trait composed of both genetic and environmental factors. Recently, scientific interest has increased in defining factors that possibly contribute to brain functional plasticity; the results might be useful to assess the relationship between MS lesion burden and clinical events, as well as explaining the well-known phenotypic heterogeneity of the disease. In this study, we explored the effect of the Val66Met brain-derived neurotrophic factor (BDNF) functional polymorphism on cognitive performances and volumetric measurements obtained by magnetic resonance imaging of the brain in a selected population of relapsing-remitting MS (RRMS) patients, with relatively short disease duration and minimal clinical disability, compared to gender, age and educational-level matched healthy subjects. We found that in the RRMS group, the BDNF Met-allele was significantly associated with the lower volume of cerebral grey matter (GM) (P = 0.005). Furthermore, a significant (P = 0.013) interaction effect between 'MS-status' and the BDNF genotype was found for GM volumes, with the result that patients carrying the BDNF Met-allele showed a higher risk of developing global GM atrophy than the homozygous Val/Val. No BDNF-related impact on global neuropsychological functions resulted in either RRMS patients or controls. Our data seem to be consistent with the reported influence of BDNF in neuronal plasticity, thus suggesting that the Met-allele might have a negative prognostic effect on cortical morphometry in RRMS patients.