Garlicin attenuates reperfusion no-reflow in a catheter-based porcine model of acute myocardial infarction
Garlicin attenuates reperfusion no-reflow in a catheter-based porcine model of acute myocardial infarction
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DOI：
10.3109/10731199.2011.649187
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发表时间：
2012-08-01
期刊：
影响因子：
--
通讯作者：
Li Xianlun
中科院分区：
文献类型：
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作者：
Yang Peng;Li Jiahui;Li Xianlun
目的：探讨大蒜素对猪急性心肌梗死(AMI)再灌注无复流的保护作用。方法：选用22头猪：假手术组6头，对照组和大蒜素组各8头。后两组左冠状动脉前降支(LAD)远端用扩张球囊闭塞2小时后再灌流3小时。大蒜素组于再灌流前注射大蒜素1.88 mg/kg至再灌流1h。分别于急性心肌梗死前、阻断后2小时、再灌流后3小时检测血流动力学指标。心肌声学造影(MCE)和病理染色评价心肌无复流面积(NRA)。采用放射免疫法检测血清促炎细胞因子和内皮素(ET)-1水平。结果：大蒜素组再灌流后和急性心肌梗死后2小时左心室收缩压(LVSP)和左心室舒张末压(LVEDP)均较对照组明显改善(P
Objective: To evaluate whether garlicin can attenuate reperfusion no-reflow in a catheter-based porcine model of acute myocardial infarction (AMI). Methods: Twenty-two swine were used: six in a sham-operation group, and eight each in the control and garlicin groups. The distal part of the left anterior descending coronary artery (LAD) in the latter two groups was occluded by a dilated balloon for 2 hr, then reperfused for 3 hr. Garlicin (1.88mg/kg) was injected just before reperfusion until reperfusion for 1 hr in the garlicin group. Hemodynamic data were examined before AMI, 2 hr after occlusion, and 3 hr after reperfusion. Myocardial contrast echocardiography (MCE) and pathological staining were performed to evaluate the myocardial no-reflow area (NRA). Serum proinflammatory cytokines and endothelin (ET)-1 were examined by radioimmunoassay. Results: Left ventricular systolic pressure (LVSP) and left ventricular end-diastolic pressure (LVEDP) significantly improved in the garlicin group after reperfusion compared with the control group and also 2hr after AMI (p