Probiotics: Definition, sources, selection, and uses
Probiotics: Definition, sources, selection, and uses
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DOI：
10.1086/523341
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发表时间：
2008-02-01
影响因子：
11.8
通讯作者：
Sanders, Mary Ellen
中科院分区：
文献类型：
--
作者：
Sanders, Mary Ellen
在美国，人们对益生菌的兴趣达到了历史最高水平，部分原因是市场上出现了新产品，美国研究人员渴望严格评估功效，消费者对潜在的治疗和预防健康益处感兴趣。美国市场是一个产品的混合袋，一些明确的和适当的评价，在对照临床研究和其他未经证实的索赔的有效性。需要验证商业产品中的益生菌含量，以确保消费者的信心。“益生菌”这个术语应该仅用于符合该术语科学标准的产品，即含有足够剂量的活微生物的产品，这些活微生物已在靶宿主研究中被证明具有健康益处。益生菌必须被鉴定到菌株水平，必须针对特定的健康目标进行表征，并且必须使用菌株和剂量配制成产品。通常认为益生菌必不可少的几个特征，如人类起源和改善肠道微生物群平衡的能力，进行了讨论。
Interest in probiotics is at an all-time high in the United States, driven in part by new products emerging in the market, by US researchers eager to evaluate efficacy claims rigorously, and by consumers interested in potential therapeutic and preventive health benefits. The US marketplace is a mixed bag of products, some well-defined and properly evaluated in controlled clinical studies and others with unsubstantiated claims of efficacy. Validation of probiotic contents in commercial products is needed to ensure consumer confidence. The term "probiotic" should be used only for products that meet the scientific criteria for this term-namely, products that contain an adequate dose of live microbes that have been documented in target-host studies to confer a health benefit. Probiotics must be identified to the level of strain, must be characterized for the specific health target, and must be formulated into products using strains and doses shown to be efficacious. Several characteristics commonly presumed to be essential to probiotics, such as human origin and the ability to improve the balance of the intestinal microbiota, are discussed.