Effect of prednisolone on inflammatory markers in pericardial tuberculosis: A pilot study.
Effect of prednisolone on inflammatory markers in pericardial tuberculosis: A pilot study.
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DOI：
10.1016/j.ijcha.2017.10.002
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发表时间：
2018-03
期刊：
影响因子：
--
通讯作者：
Wilkinson KA
中科院分区：
文献类型：
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作者：
Shenje J;Lai RP;Ross IL;Mayosi BM;Wilkinson RJ;Ntsekhe M;Wilkinson KA
心包紊乱是心脏病的常见原因，而在发展中国家，心包炎最常见的原因是结核性心包炎。已有研究表明，在标准抗结核治疗的基础上加用强的松龙可降低缩窄性心包炎的发生率。我们进行了一项初步研究，以评估强的松龙辅助治疗对心包结核中炎症标志物浓度的影响，以揭示心包结核发病的免疫学机制。从14例心包结核患者的多个时间点采集心包液、血浆和唾液样本。采用多重Luminex分析和酶联免疫吸附试验检测炎症标志物。在来自14名患者的样本中，我们证实了疾病部位的强烈分区免疫反应，并发现强的松龙在治疗8小时后显著降低了血浆中的IL-6浓度，在24小时内显著降低了唾液中的IL-1β浓度，以及心包液和唾液中的IL-8浓度。监测辅助免疫疗法在血浆或唾液中的早期效果是心包炎的一种可能性。
Pericardial disorders are a common cause of heart disease, and the most common cause of pericarditis in developing countries is tuberculous (TB) pericarditis. It has been shown that prednisolone added to standard anti-TB therapy leads to a lower rate of constrictive pericarditis. We conducted a pilot study to evaluate the effect of adjunctive prednisolone treatment on the concentration of inflammatory markers in pericardial tuberculosis, in order to inform immunological mechanisms at the disease site. Pericardial fluid, plasma and saliva samples were collected from fourteen patients with pericardial tuberculosis, at multiple time points. Inflammatory markers were measured using multiplex luminex analysis and ELISA. In samples from 14 patients we confirmed a strongly compartmentalized immune response at the disease site and found that prednisolone significantly reduced IL-6 concentrations in plasma by 8 hours of treatment, IL-1beta concentrations in saliva, as well as IL-8 concentrations in both pericardial fluid and saliva by 24 hours. Monitoring the early effect of adjunctive immunotherapy in plasma or saliva is a possibility in pericarditis.