IgG-Based Elimination Diet in Migraine Plus Irritable Bowel Syndrome
IgG-Based Elimination Diet in Migraine Plus Irritable Bowel Syndrome
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DOI：
10.1111/j.1526-4610.2012.02296.x
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发表时间：
2013-03-01
期刊：
影响因子：
5
通讯作者：
Tozun, Nurdan
中科院分区：
文献类型：
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作者：
Aydinlar, Elif Ilgaz;Dikmen, Pinar Yalinay;Tozun, Nurdan
目标。评估基于免疫球蛋白 G (IgG) 的消除饮食对肠易激综合征 (IBS) 偏头痛患者的治疗潜力。背景。在过去的研究中，禁食被认为是治疗偏头痛和肠易激综合症患者的一种有效且廉价的治疗策略。方法。这项双盲、随机、对照、交叉临床试验共纳入了 21 名被诊断患有偏头痛和 IBS 的患者（平均[标准差]年龄：38.0[11.2]岁；85.7% 女性），该试验由基线（常规饮食）、第一饮食（消除或激发饮食）和第二饮食（消除或激发饮食交替）阶段和 4 次就诊组成。结果。针对 270 种食物过敏原的 IgG 抗体测试显示平均（标准差）反应计数为 23.1 (14.1)。与基线水平相比，消除饮食本身与发作次数显着减少相关（4.8 [2.1] vs 2.7 [2.0]；P
Objectives. To evaluate therapeutic potential of the immunoglobulin G (IgG)-based elimination diet among migraine patients with irritable bowel syndrome (IBS). Background. Food elimination has been suggested as an effective and inexpensive therapeutic strategy in patients with migraine and concomitant IBS in the past studies. Methods. A total of 21 patients (mean [standard deviation] age: 38.0 [11.2] years; 85.7% females) diagnosed with migraine and IBS were included in this double-blind, randomized, controlled, cross-over clinical trial composed of baseline (usual diet), first diet (elimination or provocation diets), and second diet (interchange of elimination or provocations diets) phases and 4 visits. Results. IgG antibody tests against 270 food allergens revealed mean (standard deviation) reaction count to be 23.1 (14.1). Compared with baseline levels, elimination diet per se was associated with significant reductions in attack count (4.8 [2.1] vs 2.7 [2.0]; P