Lignans: diversity, biosynthesis, and function
Lignans: diversity, biosynthesis, and function
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DOI：
10.1021/bk-1995-0588.ch013
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
N. Lewis;M. Kato;N. Lopes;L. Davin
中科院分区：
文献类型：
--
作者：
N. Lewis;M. Kato;N. Lopes;L. Davin
亚马逊地区拥有世界上最重要的植物生物多样性资源库之一，对其进行细致而持久的管理是我们这一代和子孙后代面临的最紧迫的问题。值得注意的是，只有一小部分植物生命被系统地、全面地研究了其（生物）化学成分和对人类的最终益处。因此，保护这种资源是至关重要的。本章讨论了一大类苯丙素代谢物（统称木脂素）的发生和分布，以及它们作为生理和药理学活性物质（如抗病毒、抗肿瘤、杀菌剂和其他生物活性物质）的日益重要的意义。基于新出现的化学分类数据和最近发现的生化途径，似乎可以在预测特定植物家族超目代表中可能存在的木脂素结构变异方面发挥高概率作用。以木脂素为例，进一步编制这些数据（在化学、生化和基因表达水平）将对植物生物多样性的“编目”具有重要意义。
The Amazonian region contains one of the world's most important repositories of plant biodiversity, whose careful and lasting stewardship is a most pressing issue facing this and future generations. Remarkably, only a tiny fraction of its plant life has been systematically and comprehensively examined for its (bio)chemical constituents and ultimate benefit to humanity. Consequently preservation of this resource is of paramount importance.This chapter addresses the occurrence and distribution of a large class of phenylpropanoid metabolites, collectively known as lignans, and their increasing significance as physiologically and pharmacologically active substances e.g., as antiviral, antitumor, biocidal and other bioactive agents.Based upon emerging chemotaxonomic data and recently discovered biochemical pathways, it appears that a high level of probability can be exercised in predicting lignan structural variants likely to be present in representatives of specific plant family superorders. Using the lignans as an example, it is proposed that further compilation of such data (at the chemical, biochemical, and gene expression levels) will be of great significance in "cataloging" plant biodiversity.