Simultaneous congenital infection with Epstein-Barr virus and cytomegalovirus.
Simultaneous congenital infection with Epstein-Barr virus and cytomegalovirus.
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同时先天性感染 Epstein-Barr 病毒和巨细胞病毒。
DOI：
10.1056/nejm198106043042306
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Huang,ES
中科院分区：
文献类型：
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作者：
Joncas,JH;Alfieri,C;Leyritz-Wills,M;Brochu,P;Jasmin,G;Boldogh,I;Huang,ES
我们以前曾报道过巨细胞病毒(CMV)基因组在先天性巨细胞病毒(CMV)感染婴儿的淋巴细胞长期培养中持续存在。1，2这些细胞中也存在EB病毒(EBV)基因组，但先天性EBV感染的存在仅仅是基于血清学证据，因为在这种情况下，自发建立淋巴母细胞系的血液直到出生后三个月才能从婴儿那里获得。我们现在已经研究了另一名婴儿，她的母亲是初产妇，出生时有先天性CMV感染的临床、实验室和病理证据。
WE have previously reported the persistence of the cytomegalovirus (CMV) genome in lymphoid cells in long-term cultures from an infant with congenital CMV infection.1,2The Epstein–Barr virus (EBV) genome was also present in these cells, but the presence of congenital EBV infection was merely presumed on the basis of serologic evidence, since blood for the spontaneous establishment of a lymphoblastoid cell line in this instance was not available from the infant until three months after birth. We have now studied another infant, born to a primigravida mother, who had clinical, laboratory, and pathological evidence of congenital CMV infection at birth . . .