Preliminary Evaluation of Phosphatidylethanol and Alcohol Consumption in Patients with Liver Disease and Hypertension
Preliminary Evaluation of Phosphatidylethanol and Alcohol Consumption in Patients with Liver Disease and Hypertension
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DOI：
10.1093/alcalc/agp039
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发表时间：
2009-09-01
影响因子：
2.8
通讯作者：
Miller, Peter M.
中科院分区：
文献类型：
--
作者：
Stewart, Scott H.;Reuben, Adrian;Miller, Peter M.
目的：本初步研究的目的是评估肝病和高血压患者的血液磷脂酰乙醇 (PEth) 与近期饮酒之间的关系。方法：在学术医疗中心招募了 21 名肝病患者和 21 名原发性高血压患者。使用经过验证的自我报告方法估算酒精消耗量，并在签约实验室通过 HPLC-MS/MS 测量血液 PEth。对戒酒者/轻度饮酒者、每天饮酒 1 至 3 杯的中度饮酒者以及饮酒超过此水平的人进行了非参数比较。使用回归方法来估计肝病、性别和年龄对 PEth 和饮酒之间关系的影响，并估计 PEth 和饮酒之间线性关系的强度。结果：三个饮酒组之间的 PEth 存在显着差异 (P < 0.001)。 PEth 与酒精之间的关系在高血压和肝病患者之间没有差异（P = 0.696），也没有因性别和年龄而异。虽然在报告的饮酒水平相似的情况下，受试者之间的 PEth 浓度存在很大差异，但消耗的乙醇量与 PEth 浓度密切相关（P < 0.001）。结论：结果支持 HPLC-MS/MS 测量的 PEth 作为有或无肝病患者过去 1 至 2 周中度至重度饮酒的有希望的标志物。 PEth 似乎对于区分戒酒或轻度饮酒与中度饮酒和重度饮酒很有用，但对于区分中度饮酒和重度饮酒可能作用有限。
Aims: The goal of this preliminary study was to evaluate the relationship between blood phosphatidylethanol (PEth) and recent drinking in patients with liver disease and hypertension. Methods: Twenty-one patients with liver disease and 21 patients with essential hypertension were recruited at an academic medical center. Alcohol consumption was estimated using validated self-report methods, and blood PEth was measured by HPLC-MS/MS at a contracted laboratory. Nonparametric comparisons were made between abstainers/light drinkers, moderate drinkers consuming between 1 and 3 drinks per day, and those drinking above this level. Regression methods were used to estimate the effects of liver disease, gender, and age on the relationship between PEth and alcohol use, and to estimate the strength of the linear relationship between PEth and drinking. Results: PEth differed significantly between the three drinking groups (P < 0.001). The relationship between PEth and alcohol did not differ between hypertension and liver disease patients (P = 0.696), nor by gender and age. While there was substantial variability between subjects in the PEth concentration given a similar level of reported drinking, the amount of ethanol consumed was strongly associated with the PEth concentration (P < 0.001). Conclusion: Results support PEth measurement by HPLC-MS/MS as a promising marker of past 1- to 2-week moderate to heavy alcohol consumption in patients with and without liver disease. PEth appears useful for differentiating abstinence or light drinking from moderate to heavy consumption, but may have limited utility for differentiating moderate from heavy alcohol use.