The effect of topical phenylpropanolamine on nasal secretion and nasal airway resistance after histamine challenge in man.
The effect of topical phenylpropanolamine on nasal secretion and nasal airway resistance after histamine challenge in man.
复制标题
局部苯丙醇胺对人类组胺激发后鼻分泌和鼻气道阻力的影响。
DOI：
10.1111/j.1365-2273.1985.tb01159.x
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
M. Bende
中科院分区：
文献类型：
--
作者：
S. Löth;M. Bende
采用安慰剂对照的双盲交叉试验，在10名健康受试者中评价了局部给予苯丙醇胺（PPA）对鼻分泌物和鼻气道阻力（NAR）的影响。将鼻分泌物收集在手帕中并称重。通过前鼻孔测压法测量NAR，并将鼻阻塞程度、分泌物和打喷嚏次数记录在评分中。PPA（25 mg/ml）显著减少鼻分泌物、NAR和阻塞程度，因此PPA可用作局部鼻减充血剂。
The effect of topically administered phenylpropanolamine (PPA) on nasal secretion and nasal airway resistance (NAR) was evaluated in a placebo controlled double blind cross-over study in 10 healthy subjects. The nasal secretion was collected in hankerchiefs and weighed. NAR was measured by anterior rhinomanometry and the degree of nasal blockage, secretion and the number of sneezes were registered in a score. PPA (25 mg/ml) significantly reduced nasal secretion, NAR and the degree of blockage and so PPA may be useful as a topical nasal decongestant.