Manganese air exposure assessment and biological monitoring in the manganese alloy production industry
Manganese air exposure assessment and biological monitoring in the manganese alloy production industry
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DOI：
10.1039/b209095c
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发表时间：
2003-02-01
影响因子：
--
通讯作者：
Thomassen, Y
中科院分区：
文献类型：
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作者：
Ellingsen, DG;Hetland, SM;Thomassen, Y
100名工人携带个人空气采样设备在三个dabs评估暴露于可吸入和可呼吸锰。一种新的四步化学分馏程序开发的锰在工作室气溶胶的形态被应用于选定的气溶胶过滤器。分析血液和尿液样本的Mn。在所有过滤器中测定的可吸入（n = 26）和可吸入（n = 167）Mn的几何平均（GM）浓度分别为254 mug m（-3）和28 mug m（-3）。仅10.6%（95%CI 8.9 - 12.5）的可吸入锰被发现在可吸入部分，当可吸入和可吸入样本平行收集被认为（n = 153对）。可吸入锰与可吸入锰之间存在高度相关性（Pearson's r = 0.70 p < 0.001）。可吸入气溶胶部分中最大含量的锰为Mn-0和Mn 2+（47.4%），而28%几乎“不溶”。B-Mn和气溶胶中Mn浓度之间的关联很弱，但U-Mn和可吸入Mn之间存在关联：“可溶性”可吸入Mn和U-Mn之间的Pearson相关系数为0.38。在生物样品中的“不溶性”组分（可能是SiMn）和Mn之间没有发现显著的关联。
One hundred workers carried personal air sampling equipment during three dabs to assess exposure to inhalable and respirable Mn. A novel four-step chemical fractionation procedure developed for the speciation of Mn in workroom aerosols was applied for selected aerosol filters. Blood and Urine Samples were analysed for Mn. The geometric mean (GM) concentrations of inhalable (n = 26) and respirable (n = 167) Mn determined in all filters were 254 mug m(-3) and 28 mug m(-3) respectively. Only 10.6% (95% CI 8.9 12.5) respirable Mn vas found in the inhalable fraction hen inhalable and respirable samples collected in parallel were considered (n = 153 pairs). There was a high correlation (Pearson's r = 0.70 p < 0.001) between respirable and inhalable Mn. The largest amounts of Mn in the inhalable aerosol fraction were found as Mn-0 and Mn2+ (47.4%) whereas 28% as practically "insoluble". The associations between B-Mn and aerosol concentrations of Mn were weak, but an association was found between U-Mn and respirable Mn: Pearson's r being 0.38 between "soluble" respirable Mn and U-Mn. No significant association was found between the "insoluble" components (probable SiMn) and Mn in biological Samples.