E-Selective Semi-Hydrogenation of Alkynes by Heterobimetallic Catalysis
E-Selective Semi-Hydrogenation of Alkynes by Heterobimetallic Catalysis
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DOI：
10.1021/jacs.5b10357
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发表时间：
2015-11-25
影响因子：
15
通讯作者：
Mankad, Neal P.
中科院分区：
文献类型：
--
作者：
Karunananda, Malkanthi K.;Mankad, Neal P.
A unique cooperative H-2 activation reaction by heterobimetallic (NHC)M'-MCp(CO)(2) complexes (NHC = N-heterocyclic carbene, M' = Cu or Ag, M = Fe or Ru) has been leveraged to develop a catalytic alkyne semi-hydrogenation transformation. The optimal AgRu catalyst gives high selectivity for converting alkynes to E-alkenes, a rare selectivity mode for reduction reactions with H-2. The transformation is tolerant of many reducible functional groups. Computational analysis of H-2 activation thermodynamics guided rational catalyst development. Bimetallic alkyne hydrogenation and alkene isomerization mechanisms are proposed.
