Influence of hepatitis B virus genotypes on the progression of chronic type B liver disease
Influence of hepatitis B virus genotypes on the progression of chronic type B liver disease
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DOI：
10.1053/jhep.2003.50036
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发表时间：
2003-01-01
期刊：
影响因子：
13.5
通讯作者：
Saisho, H
中科院分区：
文献类型：
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作者：
Sumi, H;Yokosuka, O;Saisho, H
为探讨B型肝炎病毒（HBV）基因型差异在肝病进展中的作用，对585例慢性HBV感染患者（包括258例经组织学证实的慢性肝病（CLD）和74例肝细胞癌（HCC））进行了检测。基因型B的晚期纤维化（F3或F4）和HCC患者的平均年龄明显大于基因型C患者（分别为P = 0.018，P = 0.024）。CLD患者中，B基因型患者活检时HBeAg阴转率和累积HBe血清转换率均显著高于C基因型患者（P45岁）。CLD和HCC中各基因型的分布非常相似（B和C：分别为11.2%和87.0%对10.8%和89.2%）。总之，我们的研究结果表明，尽管基因型B的患者发生HBe血清转换较早，肝纤维化进展较慢，HCC发展较慢，但基因型B和C相关慢性肝病患者进展为晚期纤维化和HCC的终生风险可能没有差异。
To investigate the hepatitis B virus (HBV) genotype-related differences in the progression of liver disease, 585 patients with chronic HBV infection including 258 with histologically verified chronic liver disease (CLD) and 74 with hepatocellular carcinoma (HCC) were examined. The mean ages of both patients with advanced fibrosis (F3 or F4) and with HCC were significantly older in genotype B than in genotype C patients (P =.018, P =.024, respectively). Both the hepatitis B e antigen (HBeAg) negativity rate at biopsy and the cumulative HBe seroconversion rate in patients with CLD were significantly higher in genotype B patients than genotype C patients (P 45 years). The distribution of each genotype between CLD and HCC was very similar (B and C: 11.2% and 87.0% vs. 10.8% and 89.2%, respectively). In conclusion, our results suggest that, although the patients with genotype B experience earlier HBe seroconversion, slower progression of liver fibrosis, and slower development of HCC, the life-long risk of progression to advanced fibrosis and development of HCC may not differ among genotypes B- and C-related chronic liver disease.