Electrical pharyngeal stimulation increases substance P level in saliva
Electrical pharyngeal stimulation increases substance P level in saliva
复制标题
咽部电刺激可增加唾液中 P 物质的水平
DOI：
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发表时间：
2016
影响因子：
3.5
通讯作者：
R. Dziewas
中科院分区：
文献类型：
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作者：
S. Suntrup;S. Bittner;S. Recker;S. Meuth;T. Warnecke;I. Suttrup;T. Marian;R. Dziewas
P物质（SP）是一种神经肽，可以增强吞咽反应。它可能作为神经递质在咽粘膜响应局部刺激。有研究认为卒中后吞咽困难可能与SP水平降低有关，因此SP可作为治疗靶点。在本初步研究中，我们评估了咽电刺激（EPS）——一种增强脑损伤后皮层重组以恢复吞咽功能的神经调节装置——是否能够增加唾液或血清中的SP。
Substance P (SP) is a neuropeptide known to enhance the swallow response. It likely acts as a neurotransmitter in the pharyngeal mucosa in response to local stimuli. It has been proposed that dysphagia after stroke may be related to reduced levels of SP, which therefore constitutes a therapeutic target. In the present pilot study, we evaluated whether electrical pharyngeal stimulation (EPS), a neuromodulation device to enhance cortical reorganization for the restoration of swallowing function after brain injury, is able to increase SP in saliva or serum.