Protein N-Glycosylation in Cardiovascular Diseases and Related Risk Factors
Protein N-Glycosylation in Cardiovascular Diseases and Related Risk Factors
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DOI：
10.1007/s12170-018-0579-4
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发表时间：
2018-06-01
影响因子：
1.9
通讯作者：
Lauc, Gordan
中科院分区：
文献类型：
--
作者：
Gudelj, Ivan;Lauc, Gordan
综述目的蛋白糖基化已被观察到与不同的疾病有关，包括心血管疾病。这些观察大多与O-糖基化有关，但N-糖基化的改变近年来受到了更多的关注。最近的研究发现，N-糖基化改变与心血管疾病有关，并通过与疾病相关的危险因素直接或间接地在疾病的发展中发挥重要作用。综述：N-糖基化的变化是心血管疾病的一个新的危险因素，在疾病的发生、发展和治疗监测方面具有重要的生物标志物潜力。
Purpose of Review Protein glycosylation has been observed to associate with different diseases, including cardiovascular diseases (CVDs). Most of these observations are related to O-glycosylation, yet N-glycosylation changes have recently gained more attention.Recent Findings N-Glycosylation alterations are associated with CVDs and play an important role in disease development: directly and indirectly through risk factors associated with the disease.Summary The changes of N-glycosylation are a new risk factor for CVDs and have significant biomarker potential for disease development, progression, and therapy monitoring.