Neural correlates of value, risk, and risk aversion contributing to decision making under risk.
Neural correlates of value, risk, and risk aversion contributing to decision making under risk.
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DOI：
10.1523/jneurosci.2614-09.2009
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发表时间：
2009-10-07
期刊：
影响因子：
--
通讯作者：
Schultz W
中科院分区：
文献类型：
--
作者：
Christopoulos GI;Tobler PN;Bossaerts P;Dolan RJ;Schultz W
风险下的决策是人类行为的核心。经济决策理论认为，价值、风险和风险厌恶影响选择行为。尽管以前的研究确认了决策参数的神经相关性，但这些相关性对实际选择的贡献尚不清楚。在两个不同的实验中，参与者在风险和安全选项之间进行选择。我们分别在腹侧纹状体和前扣带回确定了离散的血氧水平依赖(BOLD)与价值和风险的相关性。值得注意的是，增加低风险和安全选项的额叶下回活动与更高的风险厌恶程度相关。重要的是，这些大胆反应的组合有效地破译了行为选择。纹状体值和扣带回的风险反应增加了风险选择的概率，而额叶下回的反应则显示出相反的关系。这些发现表明，决策因素之间的大胆关联适合理想的观察者来检测行为选择。更广泛地说，这些生物学数据有助于风险下的实际决策的理论决策参数的有效性。
Decision-making under risk is central to human behavior. Economic decision theory suggests that value, risk and risk aversion influence choice behavior. Although previous studies identified neural correlates of decision parameters, the contribution of these correlates to actual choices is unknown. In two different experiments, participants chose between risky and safe options. We identified discrete blood-oxygen-level-dependent (BOLD) correlates of value and risk in the ventral striatum and anterior cingulate, respectively. Notably, increasing inferior frontal gyrus activity to low risk and safe options correlated with higher risk aversion. Importantly, the combination of these BOLD responses effectively decoded the behavioral choice. Striatal value and cingulate risk responses increased the probability of a risky choice, whereas inferior frontal gyrus responses showed the inverse relationship. These findings suggest that the BOLD correlates of decision factors are appropriate for an ideal observer to detect behavioral choices. More generally, these biological data contribute to the validity of the theoretical decision parameters for actual decisions under risk.