A family of cyclin D homologs from plants differentially controlled by growth regulators and containing the conserved retinoblastoma protein interaction motif.
A family of cyclin D homologs from plants differentially controlled by growth regulators and containing the conserved retinoblastoma protein interaction motif.
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DOI：
10.1105/tpc.7.1.85
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
R. Soni;J. P. Carmichael;Z. Shah;J. Murray
中科院分区：
文献类型：
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作者：
R. Soni;J. P. Carmichael;Z. Shah;J. Murray
在拟南芥中，通过互补G1期细胞周期蛋白缺陷的酵母菌株，鉴定了一个新的三个相关细胞周期蛋白家族。个别成员显示组织特异性表达，并在其他植物物种中保守。它们形成了一组独特的植物细胞周期蛋白，我们将其命名为δ型细胞周期蛋白，以表明它们与哺乳动物D型细胞周期蛋白的相似性。δ和D细胞周期蛋白之间的序列关系包括N-末端序列LXCXE。该基序最初在某些病毒癌蛋白中鉴定，并且强烈涉及与视网膜母细胞瘤蛋白pRb的结合。与哺乳动物细胞周期蛋白D类似，这些植物同源物可以介导生长和植物激素信号进入植物细胞周期。为了支持这一假设，我们表明，对悬浮培养的细胞的再刺激，细胞周期蛋白δ 3是迅速诱导的植物生长调节剂细胞分裂素和细胞周期蛋白δ 2诱导的碳源。
A new family of three related cyclins has been identified in Arabidopsis by complementation of a yeast strain deficient in G1 cyclins. Individual members show tissue-specific expression and are conserved in other plant species. They form a distinctive group of plant cyclins, which we named delta-type cyclins to indicate their similarities with mammalian D-type cyclins. The sequence relationships between delta and D cyclins include the N-terminal sequence LXCXE. This motif was originally identified in certain viral oncoproteins and is strongly implicated in binding to the retinoblastoma protein pRb. By analogy to mammalian cyclin D, these plant homologs may mediate growth and phytohormonal signals into the plant cell cycle. In support of this hypothesis, we show that, on restimulation of suspension-cultured cells, cyclin delta 3 is rapidly induced by the plant growth regulator cytokinin and cyclin delta 2 is induced by carbon source.