Elevated alanine aminotransferase predicts new-onset type 2 diabetes independently of classical risk factors, metabolic syndrome, and C-reactive protein in the West of Scotland Coronary Prevention Study
Elevated alanine aminotransferase predicts new-onset type 2 diabetes independently of classical risk factors, metabolic syndrome, and C-reactive protein in the West of Scotland Coronary Prevention Study
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DOI：
10.2337/diabetes.53.11.2855
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发表时间：
2004-11-01
期刊：
影响因子：
7.7
通讯作者：
Shepherd, J
中科院分区：
文献类型：
--
作者：
Sattar, N;Scherbakova, O;Shepherd, J
我们研究了血清丙氨酸氨基转移酶（ALT）与代谢综合征特征的相关性，以及它是否能独立于苏格兰西部冠状动脉预防研究中的5,974名男性的常规测量因素预测糖尿病事件。在4.9年的随访中，共有139名男性新发糖尿病。ALT水平随着代谢综合征异常数量的增加而逐渐升高，从无代谢综合征异常的20.9 ± 7.6单位/升（平均值±标准差）到有4个或4个以上代谢综合征异常的28.1 ± 10.1单位/升（P < 0.001）。在单变量分析中，ALT在前四分位数（ALT大于或等于29单位/升）的男性与在后四分位数的男性相比，患糖尿病的风险增加（风险比3.38 [95%CI 1.99-5.73]）。
We examined the association of serum alanine aminotransferase (ALT) with features of the metabolic syndrome and whether it predicted incident diabetes independently of routinely measured factors in 5,974 men in the West of Scotland Coronary Prevention Study. A total of 139 men developed new diabetes over 4.9 years of follow-up. ALT, but not aspartate aminotransferase, levels increased progressively with the increasing number of metabolic syndrome abnormalities from (means +/- SD) 20.9 +/- 7.6 units/l in those with none to 28.1 +/- 10.1 units/l in those with four or more (P < 0.001). In a univariate analysis, men with ALT in the top quartile (ALT greater than or equal to29 units/l) had an elevated risk for diabetes (hazard ratio 3.38 [95% CI 1.99-5.73]) versus those in the bottom quartile (