Clinical factors associated with retinopathy of prematurity.
Clinical factors associated with retinopathy of prematurity.
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与早产儿视网膜病变相关的临床因素。
DOI：
10.1136/adc.63.5.522
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发表时间：
1988
影响因子：
5.2
通讯作者：
Royal
中科院分区：
文献类型：
--
作者：
A. Prendiville;W. E. Schulenburg;Royal
在1983年9月至1986年6月期间进行了一项前瞻性研究，以确定出生时体重小于1500克的早产儿视网膜病变的发生率和严重程度，以及与妊娠少于31周的早产儿视网膜病变发展相关的危险因素。144名婴儿符合纳入研究的条件。总共检查了140名出生体重低于1500克的婴儿，其中42名（30%）患有早产儿视网膜病变。这些婴儿中有15名进展为晚期疾病（III期或IV期）。117例妊娠少于31周，34例（29%）发生早产儿视网膜病变。前瞻性地收集了先前显示与疾病发展相关的34个危险因素，并使用多元逻辑回归分析来确定独立显著变量。三个危险因素：酸中毒，pH值小于7.2的次数；高氧，动脉氧张力大于12 kPa的次数；并且发现胎龄与早产儿视网膜病变的发展是独立相关的。这些发现提示酸中毒可能是该病发病的一个重要病因因素。
In the period from September 1983 until June 1986 a prospective study was carried out to determine the incidence and severity of retinopathy of prematurity in inborn infants of less than 1500 g at birth and the risk factors associated with the development of retinopathy of prematurity in infants of less than 31 weeks' gestation. One hundred and forty four infants were eligible for inclusion in the study. Altogether 140 infants of less than 1500 g birth weight were examined, 42 (30%) of whom developed retinopathy of prematurity. Fifteen of these infants had progression to advanced disease (stage III or stage IV). One hundred and seventeen of the infants were of less than 31 weeks' gestation and 34 (29%) of them developed retinopathy of prematurity. Thirty four risk factors shown previously to be associated with the development of the disease were collected prospectively and analysed using multiple logistic regression analysis to determine the independently significant variables. Three risk factors: acidosis, the number of times that the pH was less than 7.2; hyperoxia, the number of times that arterial oxygen tension was greater than 12 kPa; and gestational age were found to be independently associated with the development of retinopathy of prematurity in these infants. These findings suggest that acidosis may be an important aetiological factor in the pathogenesis of this disease.